Screening of antipsychotic drugs by wide-bore capillary gas chromatography with nitrogen phosphorus detection - Detection levels in plasma

H. Tokunaga, Keiko Kudo, T. Imamura, N. Jitsufuchi, T. Nagata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The detection levels of 12 antipsychotic drugs as ascertained from drug screening were examined in order to rise the screening results effectively for treatment of patients or medico-legal examinations in cases of poisoning. Wide bore capillary gas chromatography with nitrogen phosphorus detection was used for the analysis. The detection limits of drugs in plasma using 3 extraction procedures, single-solvent, 3-step solvent and solid phase extractions were 50 100 ng/ml, 10 200 ng/ml and 5 50 ng/ml, respectively. The detection limits were compared with blood levels previously reported in the literature. Only 4 drugs were detected at the therapeutic level, thioridazine, floropipamide, sultopride and oxypertine using the single- solvent extraction procedure. Using the 3-step solvent extraction procedure, chlorpromazine, levomepromazine and zotepine in addition to the above 4 drugs were detected. Using the solid-phase extraction procedure, 8 of 12 drugs were able to be detected at the therapeutic level, with the exception of perphenazine, haloperidol, bromperidol and nemonapride. These data were proved to be useful for a rapid forensic diagnosis.

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalJapanese Journal of Legal Medicine
Volume50
Issue number3
Publication statusPublished - Aug 1 1996

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Gas Chromatography
Phosphorus
Antipsychotic Agents
Nitrogen
Solid Phase Extraction
Pharmaceutical Preparations
Limit of Detection
Methotrimeprazine
Perphenazine
Thioridazine
Preclinical Drug Evaluations
Chlorpromazine
Haloperidol
Poisoning
Therapeutics

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Law

Cite this

Screening of antipsychotic drugs by wide-bore capillary gas chromatography with nitrogen phosphorus detection - Detection levels in plasma. / Tokunaga, H.; Kudo, Keiko; Imamura, T.; Jitsufuchi, N.; Nagata, T.

In: Japanese Journal of Legal Medicine, Vol. 50, No. 3, 01.08.1996, p. 196-202.

Research output: Contribution to journalArticle

Tokunaga, H. ; Kudo, Keiko ; Imamura, T. ; Jitsufuchi, N. ; Nagata, T. / Screening of antipsychotic drugs by wide-bore capillary gas chromatography with nitrogen phosphorus detection - Detection levels in plasma. In: Japanese Journal of Legal Medicine. 1996 ; Vol. 50, No. 3. pp. 196-202.
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