The detection levels of 12 antipsychotic drugs as ascertained from drug screening were examined in order to rise the screening results effectively for treatment of patients or medico-legal examinations in cases of poisoning. Wide bore capillary gas chromatography with nitrogen phosphorus detection was used for the analysis. The detection limits of drugs in plasma using 3 extraction procedures, single-solvent, 3-step solvent and solid phase extractions were 50 100 ng/ml, 10 200 ng/ml and 5 50 ng/ml, respectively. The detection limits were compared with blood levels previously reported in the literature. Only 4 drugs were detected at the therapeutic level, thioridazine, floropipamide, sultopride and oxypertine using the single- solvent extraction procedure. Using the 3-step solvent extraction procedure, chlorpromazine, levomepromazine and zotepine in addition to the above 4 drugs were detected. Using the solid-phase extraction procedure, 8 of 12 drugs were able to be detected at the therapeutic level, with the exception of perphenazine, haloperidol, bromperidol and nemonapride. These data were proved to be useful for a rapid forensic diagnosis.
|Number of pages||7|
|Journal||Japanese Journal of Legal Medicine|
|Publication status||Published - Aug 1 1996|
All Science Journal Classification (ASJC) codes
- Health Policy