Screening of Selected Stingless Bee Honey Varieties for ACE2-Spike Protein-Binding Inhibition Activity: A Potential Preventive Medicine Against SARS-Cov-2 Infection

Enos Tangke Arung, Rico Ramadhan, Liidza Diana Mandzilkh, Prasetia Aktavinaldy Santoso, Masako Matsumoto, Maki Nagata, Irawan Wijaya Kusuma, Swandari Paramita, Sukemi, Yadi, Naomichi Takemoto, Yhiya Amen, Syafrizal, Kuniyoshi Shimizu, Nataniel Tandirogang

Research output: Contribution to journalArticlepeer-review

Abstract

The broader objective of this study is to identify natural materials that might inhibit the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We have focused on stingless bee honey, which has a unique taste that is both sweet and sour and sometimes bitter. We screened 12 samples of honey from 11 species of stingless bees using an angiotensin-converting enzyme 2 (ACE2)-spike protein-binding assay and phytochemical analysis. Ten of the samples showed inhibition above 50% in this assay system. Most of the honey contained tannins, alkaloids, flavonoids, triterpenoids, carotenoids and carbohydrates. Our findings in this in vitro study showed that honey from stingless bees may have a potent effect against SARS-CoV-2 infection by inhibiting the ACE2-spike protein-binding.

Original languageEnglish
Pages (from-to)146-153
Number of pages8
JournalMalaysian Journal of Medical Sciences
Volume29
Issue number5
DOIs
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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