TY - JOUR
T1 - Search of type 2 diabetes susceptibility gene on chromosome 20q
AU - Takeuchi, F.
AU - Yanai, K.
AU - Inomata, H.
AU - Kuzuya, N.
AU - Kajio, H.
AU - Honjo, S.
AU - Takeda, N.
AU - Kaburagi, Y.
AU - Yasuda, K.
AU - Shirasawa, S.
AU - Sasazuki, T.
AU - Kato, N.
N1 - Funding Information:
This work was supported by the grant from the Program for Promotion of Fundamental Studies in Health Sciences of Pharmaceuticals and Medical Devices Agency (PMDA) and that of the National Institute of Biomedical Innovation (NIBI). We thank Ms. Mika Higashida and Ms. Hisae Shiina, and Dr. Kei Fujimoto and Dr. Kanae Yasuda for their help in data and sample collection.
PY - 2007/6/15
Y1 - 2007/6/15
N2 - Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4α (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P = 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.
AB - Significant evidence of linkage to type 2 diabetes (T2D) has been shown in a relatively broad region on chromosome 20q, where the hepatocyte nuclear factor-4α (HNF4A) has been noted as a positional candidate. To systematically evaluate genetic susceptibility to T2D in the relevant region, we examined the disease association by using 1145 SNPs in two-step screening in the Japanese population. The marker screening enabled us to identify significant disease association in the lipopolysaccharide binding protein (LBP) but not in the HNF4A locus. In a 17.7-Mb interval screened, the strongest association was identified for a SNP, rs2232592, located in the intron of LBP, with an estimated odds ratio of 1.73 (95% CI 1.30-2.31) (P = 0.0002) in the whole study panel involving 675 case and 474 control subjects. Our data suggest that the LBP gene may confer genetic susceptibility to T2D and this warrants further replication study.
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U2 - 10.1016/j.bbrc.2007.04.063
DO - 10.1016/j.bbrc.2007.04.063
M3 - Article
C2 - 17466274
AN - SCOPUS:34247873188
VL - 357
SP - 1100
EP - 1106
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -
