Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)

Ghislain Wabo Fotso, Justin Kamga, Bathelemy Ngameni, Shota Uesugi, Misa Ohno, Ken Ichi Kimura, Hiroyuki Momma, Eunsang Kwon, Hiroshi Furuno, Yoshihito Shiono, Simo K. Ingrid, Samuel O. Yeboah, Bonaventure T. Ngadjui

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.

    Original languageEnglish
    Pages (from-to)1981-1987
    Number of pages7
    JournalNatural Product Research
    Volume31
    Issue number17
    DOIs
    Publication statusPublished - 2017

    All Science Journal Classification (ASJC) codes

    • Analytical Chemistry
    • Biochemistry
    • Plant Science
    • Organic Chemistry

    Fingerprint Dive into the research topics of 'Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)'. Together they form a unique fingerprint.

    Cite this