Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)

Ghislain Wabo Fotso, Justin Kamga, Bathelemy Ngameni, Shota Uesugi, Misa Ohno, Ken Ichi Kimura, Hiroyuki Momma, Eunsang Kwon, Hiroshi Furuno, Yoshihito Shiono, Simo K. Ingrid, Samuel O. Yeboah, Bonaventure T. Ngadjui

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.

Original languageEnglish
Pages (from-to)1981-1987
Number of pages7
JournalNatural Product Research
Volume31
Issue number17
DOIs
Publication statusPublished - Jan 1 2017

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Albizzia
Mimosoideae
Metabolites
secondary metabolites
Inhibitory Concentration 50
inhibitory concentration 50
Steroids
Cells
Nuclear magnetic resonance
lupeol
glycols
HeLa Cells
triterpenoids
steroids
bark
Neoplasms
Albizia glaberrima
butin
fustin

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Fotso, G. W., Kamga, J., Ngameni, B., Uesugi, S., Ohno, M., Kimura, K. I., ... Ngadjui, B. T. (2017). Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). Natural Product Research, 31(17), 1981-1987. https://doi.org/10.1080/14786419.2016.1269097

Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). / Fotso, Ghislain Wabo; Kamga, Justin; Ngameni, Bathelemy; Uesugi, Shota; Ohno, Misa; Kimura, Ken Ichi; Momma, Hiroyuki; Kwon, Eunsang; Furuno, Hiroshi; Shiono, Yoshihito; Ingrid, Simo K.; Yeboah, Samuel O.; Ngadjui, Bonaventure T.

In: Natural Product Research, Vol. 31, No. 17, 01.01.2017, p. 1981-1987.

Research output: Contribution to journalArticle

Fotso, GW, Kamga, J, Ngameni, B, Uesugi, S, Ohno, M, Kimura, KI, Momma, H, Kwon, E, Furuno, H, Shiono, Y, Ingrid, SK, Yeboah, SO & Ngadjui, BT 2017, 'Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)', Natural Product Research, vol. 31, no. 17, pp. 1981-1987. https://doi.org/10.1080/14786419.2016.1269097
Fotso, Ghislain Wabo ; Kamga, Justin ; Ngameni, Bathelemy ; Uesugi, Shota ; Ohno, Misa ; Kimura, Ken Ichi ; Momma, Hiroyuki ; Kwon, Eunsang ; Furuno, Hiroshi ; Shiono, Yoshihito ; Ingrid, Simo K. ; Yeboah, Samuel O. ; Ngadjui, Bonaventure T. / Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae). In: Natural Product Research. 2017 ; Vol. 31, No. 17. pp. 1981-1987.
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