TY - JOUR
T1 - Secondary metabolites with antiproliferative effects from Albizia glaberrima var glabrescens Oliv. (Mimosoideae)
AU - Fotso, Ghislain Wabo
AU - Kamga, Justin
AU - Ngameni, Bathelemy
AU - Uesugi, Shota
AU - Ohno, Misa
AU - Kimura, Ken Ichi
AU - Momma, Hiroyuki
AU - Kwon, Eunsang
AU - Furuno, Hiroshi
AU - Shiono, Yoshihito
AU - Ingrid, Simo K.
AU - Yeboah, Samuel O.
AU - Ngadjui, Bonaventure T.
N1 - Funding Information:
This work was supported by the Organisation for the Prohibition of Chemical Weapons. G.W.F is grateful to OPCW (Organisation for the Prohibition of Chemical Weapons) for three months financial support (Travel grant and maintenance allowance) and the Network of Analytical and Bioassay Services in Africa (NABSA) for providing research facilities at the University of Botswana. We express our gratitude to Dr Kenta Goto, Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, for supporting the measurement of the CD spectra. Drs Chi Fru and Fokunang are acknowledged for reading through the manuscript.
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017
Y1 - 2017
N2 - A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.
AB - A new 5-dehydroxyflavan, namely Albiziaflavan B or (+)-(2R, 3S, 4R)-3′,4′, 7-trihydroxy-4-methoxy-2,3-trans-flavan-3,4-trans-diol (1) was isolated from the root bark of Albizia glaberrima, together with six known compounds including three flavans: (+)-mollisacacidin (2), (+)-fustin (3) and butin (4); two steroids: chondrillasterol (5) and chondrillasterone (6), and a triterpenoid: lupeol (7). The structure of 1 was established by detailed analysis of its spectroscopic data, especially 1D and 2D NMR spectra, HRESIMS and CD data. Compounds 1–6 were assayed for their antiproliferative effects on two human cancer cells, HeLa at 50 μM (n = 2) and HL60 at 20 μM (n = 2). Compound 3 and 4 were the most active on HL60 with IC50 of 8.1 and 8.3 μM, respectively. Compound 6 was the most active with an IC50 of 4.6 μM on HeLa.
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U2 - 10.1080/14786419.2016.1269097
DO - 10.1080/14786419.2016.1269097
M3 - Article
C2 - 28103742
AN - SCOPUS:85010006052
SN - 1478-6419
VL - 31
SP - 1981
EP - 1987
JO - Natural Product Research
JF - Natural Product Research
IS - 17
ER -
