Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Noriaki Kawano; Shunou Nakamura; Kousuke Mochida; Shuro Yoshida; Takuro Kuriyama; Takashi Nakaike; Tomonori Shimokawa; Taro Tochigi; Kiyoshi Yamashita; Koichi Mashiba; Ikuo Kikuchi; Aina Takarabe; Sayaka Moriguchi; Yasuo Mori; Katsuto Takenaka; Kazuya Shimoda; Hidenobu Ochiai; Masahiro Amano

doi:10.2169/internalmedicine.8618-21

Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Noriaki Kawano, Shunou Nakamura, Kousuke Mochida, Shuro Yoshida, Takuro Kuriyama, Takashi Nakaike, Tomonori Shimokawa, Taro Tochigi, Kiyoshi Yamashita, Koichi Mashiba, Ikuo Kikuchi, Aina Takarabe, Sayaka Moriguchi, Yasuo Mori, Katsuto Takenaka, Kazuya Shimoda, Hidenobu Ochiai, Masahiro Amano

Research output: Contribution to journal › Article › peer-review

Abstract

Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

Original language	English
Pages (from-to)	2771-2774
Number of pages	4
Journal	Internal Medicine
Volume	61
Issue number	18
DOIs	https://doi.org/10.2169/internalmedicine.8618-21
Publication status	Published - 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2169/internalmedicine.8618-21

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Kawano, N., Nakamura, S., Mochida, K., Yoshida, S., Kuriyama, T., Nakaike, T., Shimokawa, T., Tochigi, T., Yamashita, K., Mashiba, K., Kikuchi, I., Takarabe, A., Moriguchi, S., Mori, Y., Takenaka, K., Shimoda, K., Ochiai, H., & Amano, M. (2022). Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia. Internal Medicine, 61(18), 2771-2774. https://doi.org/10.2169/internalmedicine.8618-21

Kawano, N, Nakamura, S, Mochida, K, Yoshida, S, Kuriyama, T, Nakaike, T, Shimokawa, T, Tochigi, T, Yamashita, K, Mashiba, K, Kikuchi, I, Takarabe, A, Moriguchi, S, Mori, Y, Takenaka, K, Shimoda, K, Ochiai, H & Amano, M 2022, 'Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia', Internal Medicine, vol. 61, no. 18, pp. 2771-2774. https://doi.org/10.2169/internalmedicine.8618-21

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title = "Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia",

abstract = "Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.",

author = "Noriaki Kawano and Shunou Nakamura and Kousuke Mochida and Shuro Yoshida and Takuro Kuriyama and Takashi Nakaike and Tomonori Shimokawa and Taro Tochigi and Kiyoshi Yamashita and Koichi Mashiba and Ikuo Kikuchi and Aina Takarabe and Sayaka Moriguchi and Yasuo Mori and Katsuto Takenaka and Kazuya Shimoda and Hidenobu Ochiai and Masahiro Amano",

note = "Funding Information: This research was funded by JSPS Grants-in-Aid for Scientific Research (C) (Grant Numbers 16K11210 and 19K09886) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Society for the Promotion of International Oto-Rhino-Laryngology (SPIO), and AMED (Grant Number JP19ek 0109410). Publisher Copyright: {\textcopyright} 2022 Japanese Society of Internal Medicine. All rights reserved.",

year = "2022",

doi = "10.2169/internalmedicine.8618-21",

language = "English",

volume = "61",

pages = "2771--2774",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

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T1 - Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

AU - Kawano, Noriaki

AU - Nakamura, Shunou

AU - Mochida, Kousuke

AU - Yoshida, Shuro

AU - Kuriyama, Takuro

AU - Nakaike, Takashi

AU - Shimokawa, Tomonori

AU - Tochigi, Taro

AU - Yamashita, Kiyoshi

AU - Mashiba, Koichi

AU - Kikuchi, Ikuo

AU - Takarabe, Aina

AU - Moriguchi, Sayaka

AU - Mori, Yasuo

AU - Takenaka, Katsuto

AU - Shimoda, Kazuya

AU - Ochiai, Hidenobu

AU - Amano, Masahiro

N1 - Funding Information: This research was funded by JSPS Grants-in-Aid for Scientific Research (C) (Grant Numbers 16K11210 and 19K09886) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, the Society for the Promotion of International Oto-Rhino-Laryngology (SPIO), and AMED (Grant Number JP19ek 0109410). Publisher Copyright: © 2022 Japanese Society of Internal Medicine. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

AB - Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

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Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Abstract

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