Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia: Report of Two Cases with Human Papillomavirus Infection

Kenji Kawano, Hideyuki Goto, Yoshihiro Takahashi, Yoshihisa Kaku, Kazunari Oobu, Shigetaka Yanagisawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Two cases of secondary oral squamous cell carcinoma (SCC), which developed in recipients of hematopoietic stem cell transplantation (HSCT) for leukemia, are reported. The first patient underwent allogeneic HSCT for chronic myelogenous leukemia at 32 years of age. He suffered from chronic graft-versus-hostdisease (GVHD) of the oral mucosa after HSCT, and has subsequently received immunosuppressive therapy. He experienced metachronous multiple SCCs in the maxillary gingiva and the dorsum of the tongue at 36 years and 40 years of age, respectively. The second patient received autologous HSCT for acute myelogenous leukemia at 22 years of age, and she did not experience GVHD after transplantation. SCC developed in the lateral border of the tongue at 27 years of age. PCR analysis detected both HPV16 and HPV18 in the tongue tumor of the first patient, and only HPV18 in that of the second patient, suggesting that the infection of high-risk HPVs was possibly involved in the development of post-HSCT oral cancers in these patients. Since risk factors for post-HSCT oral SCC are not yet well recognized, long-term close follow-up is necessary for the early detection of secondary oral cancers in all transplant recipients.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalOral Science International
Volume4
Issue number2
DOIs
Publication statusPublished - Jan 1 2007

Fingerprint

Papillomavirus Infections
Hematopoietic Stem Cell Transplantation
Mouth
Young Adult
Squamous Cell Carcinoma
Leukemia
Tongue
Mouth Neoplasms
Transplants
Mouth Mucosa
Gingiva
Immunosuppressive Agents
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Acute Myeloid Leukemia
Transplantation
Polymerase Chain Reaction
Infection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia : Report of Two Cases with Human Papillomavirus Infection. / Kawano, Kenji; Goto, Hideyuki; Takahashi, Yoshihiro; Kaku, Yoshihisa; Oobu, Kazunari; Yanagisawa, Shigetaka.

In: Oral Science International, Vol. 4, No. 2, 01.01.2007, p. 110-116.

Research output: Contribution to journalArticle

@article{6caab6bd36ed4246a4f23ac0c4b1af20,
title = "Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia: Report of Two Cases with Human Papillomavirus Infection",
abstract = "Two cases of secondary oral squamous cell carcinoma (SCC), which developed in recipients of hematopoietic stem cell transplantation (HSCT) for leukemia, are reported. The first patient underwent allogeneic HSCT for chronic myelogenous leukemia at 32 years of age. He suffered from chronic graft-versus-hostdisease (GVHD) of the oral mucosa after HSCT, and has subsequently received immunosuppressive therapy. He experienced metachronous multiple SCCs in the maxillary gingiva and the dorsum of the tongue at 36 years and 40 years of age, respectively. The second patient received autologous HSCT for acute myelogenous leukemia at 22 years of age, and she did not experience GVHD after transplantation. SCC developed in the lateral border of the tongue at 27 years of age. PCR analysis detected both HPV16 and HPV18 in the tongue tumor of the first patient, and only HPV18 in that of the second patient, suggesting that the infection of high-risk HPVs was possibly involved in the development of post-HSCT oral cancers in these patients. Since risk factors for post-HSCT oral SCC are not yet well recognized, long-term close follow-up is necessary for the early detection of secondary oral cancers in all transplant recipients.",
author = "Kenji Kawano and Hideyuki Goto and Yoshihiro Takahashi and Yoshihisa Kaku and Kazunari Oobu and Shigetaka Yanagisawa",
year = "2007",
month = "1",
day = "1",
doi = "10.11277/osi.4.110",
language = "English",
volume = "4",
pages = "110--116",
journal = "Oral Science International",
issn = "1348-8643",
publisher = "The Japanese Stomatological Society",
number = "2",

}

TY - JOUR

T1 - Secondary Squamous Cell Carcinoma of the Oral Cavity in Young Adults after Hematopoietic Stem Cell Transplantation for Leukemia

T2 - Report of Two Cases with Human Papillomavirus Infection

AU - Kawano, Kenji

AU - Goto, Hideyuki

AU - Takahashi, Yoshihiro

AU - Kaku, Yoshihisa

AU - Oobu, Kazunari

AU - Yanagisawa, Shigetaka

PY - 2007/1/1

Y1 - 2007/1/1

N2 - Two cases of secondary oral squamous cell carcinoma (SCC), which developed in recipients of hematopoietic stem cell transplantation (HSCT) for leukemia, are reported. The first patient underwent allogeneic HSCT for chronic myelogenous leukemia at 32 years of age. He suffered from chronic graft-versus-hostdisease (GVHD) of the oral mucosa after HSCT, and has subsequently received immunosuppressive therapy. He experienced metachronous multiple SCCs in the maxillary gingiva and the dorsum of the tongue at 36 years and 40 years of age, respectively. The second patient received autologous HSCT for acute myelogenous leukemia at 22 years of age, and she did not experience GVHD after transplantation. SCC developed in the lateral border of the tongue at 27 years of age. PCR analysis detected both HPV16 and HPV18 in the tongue tumor of the first patient, and only HPV18 in that of the second patient, suggesting that the infection of high-risk HPVs was possibly involved in the development of post-HSCT oral cancers in these patients. Since risk factors for post-HSCT oral SCC are not yet well recognized, long-term close follow-up is necessary for the early detection of secondary oral cancers in all transplant recipients.

AB - Two cases of secondary oral squamous cell carcinoma (SCC), which developed in recipients of hematopoietic stem cell transplantation (HSCT) for leukemia, are reported. The first patient underwent allogeneic HSCT for chronic myelogenous leukemia at 32 years of age. He suffered from chronic graft-versus-hostdisease (GVHD) of the oral mucosa after HSCT, and has subsequently received immunosuppressive therapy. He experienced metachronous multiple SCCs in the maxillary gingiva and the dorsum of the tongue at 36 years and 40 years of age, respectively. The second patient received autologous HSCT for acute myelogenous leukemia at 22 years of age, and she did not experience GVHD after transplantation. SCC developed in the lateral border of the tongue at 27 years of age. PCR analysis detected both HPV16 and HPV18 in the tongue tumor of the first patient, and only HPV18 in that of the second patient, suggesting that the infection of high-risk HPVs was possibly involved in the development of post-HSCT oral cancers in these patients. Since risk factors for post-HSCT oral SCC are not yet well recognized, long-term close follow-up is necessary for the early detection of secondary oral cancers in all transplant recipients.

UR - http://www.scopus.com/inward/record.url?scp=79551637437&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551637437&partnerID=8YFLogxK

U2 - 10.11277/osi.4.110

DO - 10.11277/osi.4.110

M3 - Article

AN - SCOPUS:79551637437

VL - 4

SP - 110

EP - 116

JO - Oral Science International

JF - Oral Science International

SN - 1348-8643

IS - 2

ER -