Seeking for the endogenous ligands for PPARγ

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Peroxisome proliferators-activated receptors gamma (PPARγ) is an isoform of PPARs which are members of the nuclear receptor superfamily and are considered as key sensors of lipid and glucose homeostasis. This ligand-activated transcription factor has been intensively studied for more than a decade and the bona fide endogenous ligand remains unknown. 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ 2) is of great interest because it affects gene transcription by binding and activating PPARγ and by covalent addition to transcription factors and signaling molecules. However, the actual concentration of 15d-PGJ2 is several orders of magnitude below the levels required to induce many of the biological reaction attributed to this molecule. This short review will focus on 15d-PGJ2 as a ligand of PPARγ and on other candidates of the endogenous ligand for the receptor.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume37
Issue number2
DOIs
Publication statusPublished - Dec 1 2005

Fingerprint

PPAR gamma
Ligands
Transcription Factors
transcription factors
receptors
Peroxisome Proliferator-Activated Receptors
Molecules
Transcription
Cytoplasmic and Nuclear Receptors
prostaglandins
homeostasis
Protein Isoforms
Homeostasis
transcription (genetics)
Genes
Lipids
Glucose
glucose
ligands
peroxisome proliferator-activated receptors

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

Cite this

Seeking for the endogenous ligands for PPARγ. / Ide, Tomomi.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 37, No. 2, 01.12.2005, p. 39-44.

Research output: Contribution to journalReview article

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