Abstract
The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.
| Original language | English |
|---|---|
| Pages (from-to) | 501-514 |
| Number of pages | 14 |
| Journal | Journal of Theoretical Biology |
| Volume | 233 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 21 2005 |
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All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Modelling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics
Cite this
Selection of initial conditions for recursive production of multicellular organisms. / Yoshida, Hiroshi; Furusawa, Chikara; Kaneko, Kunihiko.
In: Journal of Theoretical Biology, Vol. 233, No. 4, 21.04.2005, p. 501-514.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selection of initial conditions for recursive production of multicellular organisms
AU - Yoshida, Hiroshi
AU - Furusawa, Chikara
AU - Kaneko, Kunihiko
PY - 2005/4/21
Y1 - 2005/4/21
N2 - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.
AB - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.
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U2 - 10.1016/j.jtbi.2004.10.026
DO - 10.1016/j.jtbi.2004.10.026
M3 - Article
C2 - 15748911
AN - SCOPUS:14644421496
VL - 233
SP - 501
EP - 514
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 4
ER -