TY - JOUR
T1 - Selection of initial conditions for recursive production of multicellular organisms
AU - Yoshida, Hiroshi
AU - Furusawa, Chikara
AU - Kaneko, Kunihiko
N1 - Funding Information:
We wish to express our gratitude to Professor Issei Mabuchi for helpful suggestions on the sea urchin. We would like to thank Dr. Koichi Fujimoto, Dr. Takuya Maeda, Dr. Hiroaki Takagi and Mr. Yohei Koyama for useful discussions and technical support. This work is supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (11CE2006; Komaba Complex Systems Life Project).
PY - 2005/4/21
Y1 - 2005/4/21
N2 - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.
AB - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.
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U2 - 10.1016/j.jtbi.2004.10.026
DO - 10.1016/j.jtbi.2004.10.026
M3 - Article
C2 - 15748911
AN - SCOPUS:14644421496
VL - 233
SP - 501
EP - 514
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 4
ER -