Selection of initial conditions for recursive production of multicellular organisms

Hiroshi Yoshida, Chikara Furusawa, Kunihiko Kaneko

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.

Original languageEnglish
Pages (from-to)501-514
Number of pages14
JournalJournal of Theoretical Biology
Volume233
Issue number4
DOIs
Publication statusPublished - Apr 21 2005

Fingerprint

Initial conditions
Cell
organisms
Poles
cells
Stem cells
Animals
Cell Differentiation
Blastomeres
Pole
Sea Urchins
Embryonic Stem Cells
Morphogenesis
Individuality
Cell Communication
Eggs
chemical concentration
blastomeres
Individual Differences
embryonic stem cells

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Cite this

Selection of initial conditions for recursive production of multicellular organisms. / Yoshida, Hiroshi; Furusawa, Chikara; Kaneko, Kunihiko.

In: Journal of Theoretical Biology, Vol. 233, No. 4, 21.04.2005, p. 501-514.

Research output: Contribution to journalArticle

Yoshida, Hiroshi ; Furusawa, Chikara ; Kaneko, Kunihiko. / Selection of initial conditions for recursive production of multicellular organisms. In: Journal of Theoretical Biology. 2005 ; Vol. 233, No. 4. pp. 501-514.
@article{860508fead9346379ba4b7a63e0a5d92,
title = "Selection of initial conditions for recursive production of multicellular organisms",
abstract = "The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.",
author = "Hiroshi Yoshida and Chikara Furusawa and Kunihiko Kaneko",
year = "2005",
month = "4",
day = "21",
doi = "10.1016/j.jtbi.2004.10.026",
language = "English",
volume = "233",
pages = "501--514",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - Selection of initial conditions for recursive production of multicellular organisms

AU - Yoshida, Hiroshi

AU - Furusawa, Chikara

AU - Kaneko, Kunihiko

PY - 2005/4/21

Y1 - 2005/4/21

N2 - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.

AB - The development of a multicellular organism is a dynamic process. Starting from one or a few cells, the organism becomes a set of cells with different types that form well-determined patterns. It is rather surprising that differentiation in cell types and formation of controlled patterns are compatible, because the former gives morphogenetic diversification whereas the latter implies recursive production of a cell ensemble, reducing individual differences. We studied this problem by taking a simple cell model with intracellular reaction dynamics of chemical concentrations, cell-cell interactions, and increase in cell numbers. We observed successive differentiation from a cell type with diverse chemicals and chaotic concentration dynamics to cell types with oscillatory or fixed-point dynamics, leading to morphogenetic diversity in a spatial pattern. We further show that, by starting from an initial object consisting of both the former cell type with diverse chemicals and the latter differentiated cell type, the recursive production of a multicellular organism with morphogenetic diversity is possible. By relating the former type to a cell in the vegetal pole and the latter to one in the animal pole, classic experimental results with separation of blastomeres in sea urchin eggs are coherently explained, while some predictions are made for in vitro morphogenesis from embryonic stem cells.

UR - http://www.scopus.com/inward/record.url?scp=14644421496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14644421496&partnerID=8YFLogxK

U2 - 10.1016/j.jtbi.2004.10.026

DO - 10.1016/j.jtbi.2004.10.026

M3 - Article

C2 - 15748911

AN - SCOPUS:14644421496

VL - 233

SP - 501

EP - 514

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

IS - 4

ER -