Selective CD27+ (Memory) B Cell Reduction and Characteristic B Cell Alteration in Drug-Naive and HAART-Treated HIV Type 1-Infected Patients

Yong Chong, Hideyuki Ikematsu, Kensuke Kikuchi, Masahiro Yamamoto, Masayuki Murata, Mika Nishimura, Shigeki Nabeshima, Seizaburo Kashiwagi, Jun Hayashi

Research output: Contribution to journalReview article

50 Citations (Scopus)

Abstract

To investigate HIV-1-related B cell disorders, the quantity of CD27 positive (CD27+) B cells and their CD38, CD95, and bcl-2 intensities were examined by flow cytometry analysis in 16 drug-naive patients, 27 highly active antiretroviral therapy (HAART)-treated patients, and 20 uninfected controls. CD27+ B cells have been recognized as memory B cells. The mean percentage of CD27+ B cells was significantly lower in drug-naive patients (11.9%) and in HAART-treated patients (16.1%) than in controls (31.4%) (p < 0.01). The intensities of CD38 and CD95 on CD27 + B cells were higher in drug-naive patients than in controls (p < 0.01 in CD95). The intensity of CD95 on CD27+ B cells in HAART-treated patients was lower than that of drug-naive patients, but significantly higher than that of controls (p < 0.01). The intensity of bcl-2 on CD27+ B cells was equivalent among the three groups. These findings suggest that disturbance of peripheral B cell composition, exemplified by CD27+ B cell reduction, exists in both drug-naive and HAART-treated HIV-1-infected patients. In addition, the augmented apoptotic state of CD27+ B cells found in HAART-treated patients with undetectable viral loads, indicated by CD95 elevation, suggests that some HIV-1-related B cell disorders last for years after effective antiviral therapy.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1 2004

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Selective CD27<sup>+</sup> (Memory) B Cell Reduction and Characteristic B Cell Alteration in Drug-Naive and HAART-Treated HIV Type 1-Infected Patients'. Together they form a unique fingerprint.

  • Cite this