Selective fluorescence detection of 8-oxoguanosine with 8-oxoG-clamp

Osamu Nakagawa, Sayaka Ono, Akira Tsujimoto, Zhichun Li, Shigeki Sasaki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

8-oxoguanosine, which is derived from the oxidation of guanosine (dG), is known to induce transversion mutations (G:C→T:A) in DNA. The compounds with a small molecular weight for recognizing 8-oxoG were designed on the basis of the structure of the G-clamp, which is reported to have selective affinity toward guanosine. The G-clamp derivatives with the additional binding units toward 8-oxoG were effectively synthesized and named "8-oxoG-clamps." The 8-oxoG-clamp completely discriminated 8-oxoG from other nucleosides by fluorescence quenching.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number6-7
DOIs
Publication statusPublished - Jun 1 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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