Selective formation of non-natural type triplexes containing TA interrupting sites with the TFO incorporating W-shape nucleic acid (WNA) analogs.

Yosuke Taniguchi, Ryo Takahashi, Keiichi Kodama, Yusuke Senko, Minoru Maeda, Shigeki Sasaki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Novel nucleoside analogs have been desired for selective formation of non-natural type triplexes containing TA or CG interrupting sites. We have previously reported that the W-shaped nucleic acid (WNA) would be a useful skeleton to develop new base analog for the formation of non-natural triplexes of antiparallel motif. In this study, we have found that triplex forming oligonucleotide (TFO) incorporating the new WNA analog, WNA-beta T, formed more stable triplex than natural triplex with high selectivity to the TA site. It is also noted that the TFO containing WNA-beta T did not form aggregates at the physiological condition of K+.

Original languageEnglish
Pages (from-to)35-36
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number2
DOIs
Publication statusPublished - 2002

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