Selective impairment of optic flow perception in amnestic mild cognitive impairment: Evidence from event-related potentials

Takao Yamasaki, Yoshinobu Goto, Yasumasa Ohyagi, Akira Monji, Shinji Munetsuna, Motozumi Minohara, Katsuko Minohara, Jun Ichi Kira, Shigenobu Kanba, Shozo Tobimatsu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Alzheimer's disease (AD) patients have visuospatial deficits due to parietal dorsal stream dysfunction. Two distinct dorsal flows have been proposed: the inferior parietal (ventro-dorsal (v-d)) and superior parietal (dorso-dorsal (d-d)) streams. We aimed to elucidate how the two dorsal streams are altered in patients with amnestic mild cognitive impairment (aMCI) and AD. Thus, the psychophysical threshold measurements and visual event-related potentials (ERPs) were recorded in patients with aMCI and AD, and in healthy old and young adults. The visual stimuli included radial optic flow (OF) derived from the v-d stream and horizontal (HO) motion conveyed from the d-d stream. The motion thresholds between aMCI patients and old adults were comparable. However, AD patients showed significantly higher motion thresholds for both stimuli compared with other groups. In lower-level ERPs, there were no significant differences in P1 (100 ms) and N1 (130 ms) for both stimuli among the groups. For higher-level ERPs, aMCI patients showed the prolonged latency of OF-specific P200 (v-d origin) and comparable latency of motion-related N170 (V5/MT origin) for both stimuli compared with old adults. In AD patients, both N170 and P200 latencies were significantly prolonged compared with other groups. P200 latency was closely correlated with the Mini-Mental State Examination score. These findings indicate that the v-d function related to OF perception is selectively impaired in aMCI, whereas AD has impairment of the distributed higher-level dorsal stream. Therefore, OF-specific P200 can be useful for detecting early functional changes of the brain in aMCI.

Original languageEnglish
Pages (from-to)695-708
Number of pages14
JournalJournal of Alzheimer's Disease
Volume28
Issue number3
DOIs
Publication statusPublished - 2012

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Optic Flow
Evoked Potentials
Alzheimer Disease
Cognitive Dysfunction
Young Adult
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Selective impairment of optic flow perception in amnestic mild cognitive impairment : Evidence from event-related potentials. / Yamasaki, Takao; Goto, Yoshinobu; Ohyagi, Yasumasa; Monji, Akira; Munetsuna, Shinji; Minohara, Motozumi; Minohara, Katsuko; Kira, Jun Ichi; Kanba, Shigenobu; Tobimatsu, Shozo.

In: Journal of Alzheimer's Disease, Vol. 28, No. 3, 2012, p. 695-708.

Research output: Contribution to journalArticle

Yamasaki, Takao ; Goto, Yoshinobu ; Ohyagi, Yasumasa ; Monji, Akira ; Munetsuna, Shinji ; Minohara, Motozumi ; Minohara, Katsuko ; Kira, Jun Ichi ; Kanba, Shigenobu ; Tobimatsu, Shozo. / Selective impairment of optic flow perception in amnestic mild cognitive impairment : Evidence from event-related potentials. In: Journal of Alzheimer's Disease. 2012 ; Vol. 28, No. 3. pp. 695-708.
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