Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

Fumi Nagatsugi; Daisaku Usui; Takeshi Kawasaki; Minoru Maeda; Shigeki Sasaki

doi:10.1016/S0960-894X(00)00666-1

Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

Fumi Nagatsugi, Daisaku Usui, Takeshi Kawasaki, Minoru Maeda, Shigeki Sasaki

Chemo-Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.

Original language	English
Pages (from-to)	343-345
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(00)00666-1
Publication status	Published - Feb 12 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00666-1

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title = "Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation",

abstract = "A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.",

author = "Fumi Nagatsugi and Daisaku Usui and Takeshi Kawasaki and Minoru Maeda and Shigeki Sasaki",

note = "Funding Information: The authors are grateful for support by Grant-in-Aid for Scientific Research on Priority Area (A), Area No. 404 to SS and for Young Scientist to FN from the Ministry of Education, Science, Sports and Culture, Japan.",

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T1 - Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

AU - Nagatsugi, Fumi

AU - Usui, Daisaku

AU - Kawasaki, Takeshi

AU - Maeda, Minoru

AU - Sasaki, Shigeki

N1 - Funding Information: The authors are grateful for support by Grant-in-Aid for Scientific Research on Priority Area (A), Area No. 404 to SS and for Young Scientist to FN from the Ministry of Education, Science, Sports and Culture, Japan.

PY - 2001/2/12

Y1 - 2001/2/12

N2 - A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.

AB - A new nucleoside derivative (2) with a butyl spacer between the sugar part and the 2-amino-6-vinylpurine motif has been synthesized. The triplex-forming oligodeoxynucleotide incorporating 2 has achieved strand- and cytidine-selective cross-linking reaction to the G-C target site mediated by triple helix formation. It has been suggested that 2 reacts with a flipping cytidine at the target site.

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Selective reaction to a flipping cytidine of the duplex DNA mediated by triple helix formation

Abstract

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