Self and nonself recognition through C-type lectin receptor, Mincle

Yasunobu Miyake, Eri Ishikawa, Tetsuaki Ishikawa, Shou Yamasaki

    Research output: Contribution to journal › Review article

    32 Citations (Scopus)

    Abstract

    Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

    Original languageEnglish
    Pages (from-to)310-313
    Number of pages4
    JournalSelf/Nonself - Immune Recognition and Signaling
    Volume1
    Issue number4
    DOIs
    Publication statusPublished - Oct 1 2010

    Fingerprint

    C-Type Lectins
    Ligands
    Mycobacterium
    Fungi
    Yeasts
    Macrophages
    Cytokines
    Proteins

    All Science Journal Classification (ASJC) codes

    • Immunology
    • Immunology and Microbiology (miscellaneous)

    Cite this

    Self and nonself recognition through C-type lectin receptor, Mincle. / Miyake, Yasunobu; Ishikawa, Eri; Ishikawa, Tetsuaki; Yamasaki, Shou.

    In: Self/Nonself - Immune Recognition and Signaling, Vol. 1, No. 4, 01.10.2010, p. 310-313.

    Research output: Contribution to journal › Review article

    Miyake, Y, Ishikawa, E, Ishikawa, T & Yamasaki, S 2010, 'Self and nonself recognition through C-type lectin receptor, Mincle', Self/Nonself - Immune Recognition and Signaling, vol. 1, no. 4, pp. 310-313. https://doi.org/10.4161/self.1.4.13736
    Miyake Y, Ishikawa E, Ishikawa T, Yamasaki S. Self and nonself recognition through C-type lectin receptor, Mincle. Self/Nonself - Immune Recognition and Signaling. 2010 Oct 1;1(4):310-313. https://doi.org/10.4161/self.1.4.13736
    Miyake, Yasunobu ; Ishikawa, Eri ; Ishikawa, Tetsuaki ; Yamasaki, Shou. / Self and nonself recognition through C-type lectin receptor, Mincle. In: Self/Nonself - Immune Recognition and Signaling. 2010 ; Vol. 1, No. 4. pp. 310-313.
    @article{e89d184ffcd24c17910d63415c4c0390,
    title = "Self and nonself recognition through C-type lectin receptor, Mincle",
    abstract = "Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.",
    author = "Yasunobu Miyake and Eri Ishikawa and Tetsuaki Ishikawa and Shou Yamasaki",
    year = "2010",
    month = "10",
    day = "1",
    doi = "10.4161/self.1.4.13736",
    language = "English",
    volume = "1",
    pages = "310--313",
    journal = "Self/Nonself - Immune Recognition and Signaling",
    issn = "1938-2030",
    publisher = "Landes Bioscience",
    number = "4",

    }

    TY - JOUR

    T1 - Self and nonself recognition through C-type lectin receptor, Mincle

    AU - Miyake, Yasunobu

    AU - Ishikawa, Eri

    AU - Ishikawa, Tetsuaki

    AU - Yamasaki, Shou

    PY - 2010/10/1

    Y1 - 2010/10/1

    N2 - Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

    AB - Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

    UR - http://www.scopus.com/inward/record.url?scp=79851493411&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79851493411&partnerID=8YFLogxK

    U2 - 10.4161/self.1.4.13736

    DO - 10.4161/self.1.4.13736

    M3 - Review article

    VL - 1

    SP - 310

    EP - 313

    JO - Self/Nonself - Immune Recognition and Signaling

    JF - Self/Nonself - Immune Recognition and Signaling

    SN - 1938-2030

    IS - 4

    ER -

    Access to Document