Abstract
Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.
Original language | English |
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Pages (from-to) | 310-313 |
Number of pages | 4 |
Journal | Self/Nonself - Immune Recognition and Signaling |
Volume | 1 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2010 |
All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Microbiology (miscellaneous)