Abstract
Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.
| Original language | English |
|---|---|
| Pages (from-to) | 310-313 |
| Number of pages | 4 |
| Journal | Self/Nonself - Immune Recognition and Signaling |
| Volume | 1 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1 2010 |
All Science Journal Classification (ASJC) codes
- Immunology
- Immunology and Microbiology (miscellaneous)
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Miyake, Y., Ishikawa, E., Ishikawa, T., & Yamasaki, S. (2010). Self and nonself recognition through C-type lectin receptor, Mincle. Self/Nonself - Immune Recognition and Signaling, 1(4), 310-313. https://doi.org/10.4161/self.1.4.13736