Self and nonself recognition through C-type lectin receptor, Mincle

Yasunobu Miyake; Eri Ishikawa; Tetsuaki Ishikawa; Sho Yamasaki

doi:10.4161/self.1.4.13736

Self and nonself recognition through C-type lectin receptor, Mincle

Yasunobu Miyake, Eri Ishikawa, Tetsuaki Ishikawa, Sho Yamasaki

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

Original language	English
Pages (from-to)	310-313
Number of pages	4
Journal	Self/Nonself - Immune Recognition and Signaling
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/self.1.4.13736
Publication status	Published - Oct 2010

All Science Journal Classification (ASJC) codes

Immunology
Immunology and Microbiology (miscellaneous)

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abstract = "Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.",

author = "Yasunobu Miyake and Eri Ishikawa and Tetsuaki Ishikawa and Sho Yamasaki",

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T1 - Self and nonself recognition through C-type lectin receptor, Mincle

AU - Miyake, Yasunobu

AU - Ishikawa, Eri

AU - Ishikawa, Tetsuaki

AU - Yamasaki, Sho

PY - 2010/10

Y1 - 2010/10

N2 - Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

AB - Mincle (also called as Clec4e or Clecsf9) is a C-type lectin receptor expressed in activated macrophages. Recently, we have reported that Mincle transduces the activation signals through ITAM-containing adaptor protein, FcRγ and induces the secretion of inflammatory cytokines. Furthermore, we and other groups have identified that Mincle recognizes a wide variety of ligands such as damaged cells, fungus, yeast and mycobacteria. These results indicate that Mincle acts as a multi-task danger receptor for both self and nonself ligands. This review summarizes the recent discoveries about the ligands and immunological roles of Mincle.

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Self and nonself recognition through C-type lectin receptor, Mincle

Abstract

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