Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging

Kosuke Morishita, Shoji Ueki, Yasufumi Fuchi, Shuhei Murayama, Tomoyo Kaneko, Nozomi Narita, Shigeki Kobayashi, Go Hirai, Ichio Aoki, Satoru Karasawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

As part of a series of investigations related to the construction of metal-free magnetic resonance imaging (MRI) contrast agents as alternatives to gadolinium agents, water-soluble biradicals, denoted as 1-AMP and 2-HEG, were prepared, in which two stable radicals were introduced to a ureabenzene framework. We found that 1-AMP possessed an amphiphilic side chain that consisted of an alkyl group and a hexaethylene glycol (HEG) chain, whereas 2-HEG possessed only an HEG chain. Accordingly, the biradicals showed self-assembly behavior due to multiple intermolecular interactions through which nanoparticles were formed in a water solution. Magnetic interaction took place in both biradicals, and the estimated interaction strength was J = 5.4 mT. Through MRI measurement, the water proton relaxivities, r1, were estimated to be 0.12 and 0.41 mM-1 s-1 for 1-AMP and 2-HEG, respectively; in other words, the r1 value for 2-HEG was approximately twice as high as that of monoradical-based contrast agents. ©

Original languageEnglish
Pages (from-to)6967-6975
Number of pages9
JournalACS Applied Nano Materials
Volume1
Issue number12
DOIs
Publication statusPublished - Dec 28 2018

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Fingerprint Dive into the research topics of 'Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging'. Together they form a unique fingerprint.

  • Cite this

    Morishita, K., Ueki, S., Fuchi, Y., Murayama, S., Kaneko, T., Narita, N., Kobayashi, S., Hirai, G., Aoki, I., & Karasawa, S. (2018). Self-Assembled Biradical Ureabenzene Nanoparticles for Magnetic Resonance Imaging. ACS Applied Nano Materials, 1(12), 6967-6975. https://doi.org/10.1021/acsanm.8b01774