Self-assembled monolayer and peptide coated nanowire devices for selective detection of C-reactive protein and E.coli without antibody

A. Yokoyama, T. Yasui, T. Goda, T. Yanagida, M. Tanaka, M. Muto, M. Okochi, N. Kaji, M. Kanai, K. Nagashima, Y. Miyahara, T. Kawai, Y. Baba

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed surface-coated nanowire device with 2-methacryloyloxyethyl phosphorylcholine self-assembled monolayer for the detection of C-reactive protein (CRP) and phage display screened specific peptide for the detection of Escherichia coli (E. coli) without antibody. In this work, for achieving high-efficient target capturing we focused on combination of nanostructure and surface coating. We fabricated zinc oxide (ZnO) nanowire devices by hydrothermal synthesis and coated their surface with materials recognizing each biomarker without antibody. 3D structure of nanowire and surface coating enhanced target capture ability.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages1156-1157
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Publication series

Name20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Yokoyama, A., Yasui, T., Goda, T., Yanagida, T., Tanaka, M., Muto, M., Okochi, M., Kaji, N., Kanai, M., Nagashima, K., Miyahara, Y., Kawai, T., & Baba, Y. (2016). Self-assembled monolayer and peptide coated nanowire devices for selective detection of C-reactive protein and E.coli without antibody. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 1156-1157). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.