Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue

Takeru Araki, Shuhei Murayama, Kazuteru Usui, Takashi Shimada, Ichio Aoki, Satoru Karasawa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this study we describe the construction of a system composed of thermally responsive molecules that can be induced to accumulate in tumor tissues by heating. EgX molecules consisting of an urea-benzene framework and oligoethylene glycol (OEG) functional groups with an emissive aminoquinoline formed nanoparticles (NPs) ∼10 nm in size at 23 °C with a fluorescence quantum yield of 7-10%. At higher temperatures, additional self-assembly occurred as a result of OEG dehydration, and the NPs grew to over 1000 nm in size; this was accompanied by low critical solution temperature behavior. EgXs accumulated in tumor tissues of mice at a body temperature of around 33-35 °C, an effect that was accelerated by external heating around the tumor to approximately 40 °C as a result of increased particle size and enhanced retention in tissue. These EgX NPs can serve as a tool for in vivo monitoring of tumor progression and response to treatment.

Original languageEnglish
Pages (from-to)2397-2403
Number of pages7
JournalNano Letters
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 12 2017

Fingerprint

Benzene Derivatives
ureas
Urea
Self assembly
self assembly
Tumors
Benzene
tumors
benzene
Tissue
Derivatives
heat
Glycols
Nanoparticles
nanoparticles
glycols
Aminoquinolines
body temperature
Heating
Molecules

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue. / Araki, Takeru; Murayama, Shuhei; Usui, Kazuteru; Shimada, Takashi; Aoki, Ichio; Karasawa, Satoru.

In: Nano Letters, Vol. 17, No. 4, 12.04.2017, p. 2397-2403.

Research output: Contribution to journalArticle

Araki, Takeru ; Murayama, Shuhei ; Usui, Kazuteru ; Shimada, Takashi ; Aoki, Ichio ; Karasawa, Satoru. / Self-Assembly Behavior of Emissive Urea Benzene Derivatives Enables Heat-Induced Accumulation in Tumor Tissue. In: Nano Letters. 2017 ; Vol. 17, No. 4. pp. 2397-2403.
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