Self-assembly of amphiphilic dendritic dipeptides into helical pores

Virgil Percec, Andrés E. Dulcey, Venkatachalapathy S.K. Balagurusamy, Yoshiko Miura, Jan Smidrkal, Mihai Peterca, Sami Hummelin, Ulrica Edlund, Steven D. Hudson, Paul A. Heiney, Hu Duan, Sergei N. Magonev, Sergei A. Vinogradov

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Abstract

Natural pore-forming proteins act as viral helical coats and transmembrane channels, exhibit antibacterial activity and are used in synthetic systems, such as for reversible encapsulation or stochastic sensing. These diverse functions are intimately linked to protein structure. The close link between protein structure and protein function makes the design of synthetic mimics a formidable challenge, given that structure formation needs to be carefully controlled on all hierarchy levels, in solution and in the bulk. In fact, with few exceptions, synthetic pore structures capable of assembling into periodically ordered assemblies that are stable in solution and in the solid state have not yet been realized. In the case of dendrimers, covalent and non-covalent coating and assembly of a range of different structures has only yielded dosed columns. Here we describe a library of amphiphilic dendritic dipeptides that self-assemble in solution and in bulk through a complex recognition process into helical pores. We find that the molecular recognition and self-assembly process is sufficiently robust to tolerate a range of modifications to the amphiphile structure, while preliminary proton transport measurements establish that the pores are functional. We expect that this class of self-assembling dendrimers will allow the design of a variety of biologically inspired systems with functional properties arising from their porous structure.

Original languageEnglish
Pages (from-to)764-768
Number of pages5
JournalNature
Volume430
Issue number7001
DOIs
Publication statusPublished - Aug 12 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

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    Percec, V., Dulcey, A. E., Balagurusamy, V. S. K., Miura, Y., Smidrkal, J., Peterca, M., Hummelin, S., Edlund, U., Hudson, S. D., Heiney, P. A., Duan, H., Magonev, S. N., & Vinogradov, S. A. (2004). Self-assembly of amphiphilic dendritic dipeptides into helical pores. Nature, 430(7001), 764-768. https://doi.org/10.1038/nature02770