Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging

Jinfeng Zhang, Wencheng Chen, Sergii Kalytchuk, King Fai Li, Rui Chen, Chihaya Adachi, Zhan Chen, Andrey L. Rogach, Guangyu Zhu, Peter K.N. Yu, Wenjun Zhang, Kok Wai Cheah, Xiaohong Zhang, Chun Sing Lee

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

In this study, we report fluorescent organic nanoprobes with intense blue, green, and orange-red emissions prepared by self-assembling three carbazole derivatives into nanorods/nanoparticles. The three compounds consist of two or four electron-donating carbazole groups linked to a central dicyanobenzene electron acceptor. Steric hindrance from the carbazole groups leads to noncoplanar 3D molecular structures favorable to fluorescence in the solid state, while the donor-acceptor structures endow the molecules with good two-photon excited emission properties. The fluorescent organic nanoprobes exhibit good water dispersibility, low cytotoxicity, superior resistance against photodegradation and photobleaching. Both one- and two-photon fluorescent imaging were shown in the A549 cell line. Two-photon fluorescence imaging with the fluorescent probes was demonstrated to be more effective in visualizing and distinguishing cellular details compared to conventional one-photon fluorescence imaging.

Original languageEnglish
Pages (from-to)11355-11365
Number of pages11
JournalACS Applied Materials and Interfaces
Volume8
Issue number18
DOIs
Publication statusPublished - May 11 2016

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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