TY - JOUR
T1 - Self-Assembly of Electron Donor-Acceptor-Based Carbazole Derivatives
T2 - Novel Fluorescent Organic Nanoprobes for Both One- and Two-Photon Cellular Imaging
AU - Zhang, Jinfeng
AU - Chen, Wencheng
AU - Kalytchuk, Sergii
AU - Li, King Fai
AU - Chen, Rui
AU - Adachi, Chihaya
AU - Chen, Zhan
AU - Rogach, Andrey L.
AU - Zhu, Guangyu
AU - Yu, Peter K.N.
AU - Zhang, Wenjun
AU - Cheah, Kok Wai
AU - Zhang, Xiaohong
AU - Lee, Chun Sing
N1 - Funding Information:
This research was supported by the National Natural Science Foundation of China (Grant 51473138), the JST, ERATO, Adachi Molecular Exciton Engineering Project, and the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/5/11
Y1 - 2016/5/11
N2 - In this study, we report fluorescent organic nanoprobes with intense blue, green, and orange-red emissions prepared by self-assembling three carbazole derivatives into nanorods/nanoparticles. The three compounds consist of two or four electron-donating carbazole groups linked to a central dicyanobenzene electron acceptor. Steric hindrance from the carbazole groups leads to noncoplanar 3D molecular structures favorable to fluorescence in the solid state, while the donor-acceptor structures endow the molecules with good two-photon excited emission properties. The fluorescent organic nanoprobes exhibit good water dispersibility, low cytotoxicity, superior resistance against photodegradation and photobleaching. Both one- and two-photon fluorescent imaging were shown in the A549 cell line. Two-photon fluorescence imaging with the fluorescent probes was demonstrated to be more effective in visualizing and distinguishing cellular details compared to conventional one-photon fluorescence imaging.
AB - In this study, we report fluorescent organic nanoprobes with intense blue, green, and orange-red emissions prepared by self-assembling three carbazole derivatives into nanorods/nanoparticles. The three compounds consist of two or four electron-donating carbazole groups linked to a central dicyanobenzene electron acceptor. Steric hindrance from the carbazole groups leads to noncoplanar 3D molecular structures favorable to fluorescence in the solid state, while the donor-acceptor structures endow the molecules with good two-photon excited emission properties. The fluorescent organic nanoprobes exhibit good water dispersibility, low cytotoxicity, superior resistance against photodegradation and photobleaching. Both one- and two-photon fluorescent imaging were shown in the A549 cell line. Two-photon fluorescence imaging with the fluorescent probes was demonstrated to be more effective in visualizing and distinguishing cellular details compared to conventional one-photon fluorescence imaging.
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U2 - 10.1021/acsami.6b03259
DO - 10.1021/acsami.6b03259
M3 - Article
C2 - 27097920
AN - SCOPUS:84974777191
VL - 8
SP - 11355
EP - 11365
JO - ACS applied materials & interfaces
JF - ACS applied materials & interfaces
SN - 1944-8244
IS - 18
ER -