Self-organized criticality theory of autoimmunity

Ken Tsumiyama, Yumi Miyazaki, Shunichi Shiozawa

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: The cause of autoimmunity, which is unknown, is investigated from a different angle, i.e., the defect in immune 'system', to explain the cause of autoimmunity. Methodology/Principal Findings: Repeated immunization with antigen causes systemic autoimmunity in mice otherwise not prone to spontaneous autoimmune diseases. Overstimulation of CD4 T cells led to the development of autoantibody-inducing CD4 T (aiCD4 T) cell which had undergone T cell receptor (TCR) revision and was capable of inducing autoantibodies. The aiCD4 T cell was induced by de novo TCR revision but not by cross-reaction, and subsequently overstimulated CD8 T cells, driving them to become antigen-specific cytotoxic T lymphocytes (CTL). These CTLs could be further matured by antigen cross-presentation, after which they caused autoimmune tissue injury akin to systemic lupus erythematosus (SLE). Conclusions/Significance: Systemic autoimmunity appears to be the inevitable consequence of over-stimulating the host's immune 'system' by repeated immunization with antigen, to the levels that surass system's self-organized criticality.

Original languageEnglish
Article numbere8382
JournalPloS one
Volume4
Issue number12
DOIs
Publication statusPublished - Dec 1 2009

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autoimmunity
T-cells
Autoimmunity
T-lymphocytes
Autoantibodies
T-Lymphocytes
autoantibodies
Immunization
Antigens
T-Cell Antigen Receptor
Immune system
antigens
Immune System
Cross-Priming
immune system
Cross Reactions
immunization
Antigen Presentation
Cytotoxic T-Lymphocytes
Systemic Lupus Erythematosus

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Tsumiyama, K., Miyazaki, Y., & Shiozawa, S. (2009). Self-organized criticality theory of autoimmunity. PloS one, 4(12), [e8382]. https://doi.org/10.1371/journal.pone.0008382

Self-organized criticality theory of autoimmunity. / Tsumiyama, Ken; Miyazaki, Yumi; Shiozawa, Shunichi.

In: PloS one, Vol. 4, No. 12, e8382, 01.12.2009.

Research output: Contribution to journalArticle

Tsumiyama, K, Miyazaki, Y & Shiozawa, S 2009, 'Self-organized criticality theory of autoimmunity', PloS one, vol. 4, no. 12, e8382. https://doi.org/10.1371/journal.pone.0008382
Tsumiyama, Ken ; Miyazaki, Yumi ; Shiozawa, Shunichi. / Self-organized criticality theory of autoimmunity. In: PloS one. 2009 ; Vol. 4, No. 12.
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