Self-setting barrier membrane for guided tissue regeneration method: Initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions

Kunio Ishikawa, Yoshiya Ueyama, Takamitsu Mano, Takahiro Koyama, Kazuomi Suzuki, Tomohiro Matsumura

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Alginate membrane was proposed as a self-setting barrier membrane that can be used for guided tissue regeneration (GTR). The alginate membrane can be prepared and placed at the bone defect during the surgical procedure. The procedure consists of two simple steps. First, the bone defect is filled with sodium alginate (Na-Alg) aqueous solution. Then calcium chloride aqueous solution is dropped on the surface of the Na-Alg aqueous solution. An alginate membrane is formed on the bone defect, keeping the inside of the bone defect filled with unreacted Na-Alg aqueous solution. In this investigation, a preliminary animal study was conducted for an initial evaluation as to whether or not the alginate membrane can be used as a barrier membrane for the GTR method. Bone defects were made in the tibiae of 15-week-old rats. The alginate membrane was made on the surface of existing bone by filling the defect with Na-Alg aqueous solution and then dropping calcium chloride aqueous solution onto the surface of the Na-Alg solution. Four weeks after surgery, the bone defect was found to be reconstructed with new bone when the defect had been covered with alginate membrane whereas the bone defect was filled only with connective tissue when it had been kept open. We concluded, therefore, that this alginate membrane may be a useful barrier membrane when the GTR method is employed.

Original languageEnglish
Pages (from-to)111-115
Number of pages5
JournalJournal of Biomedical Materials Research
Volume47
Issue number2
DOIs
Publication statusPublished - Sep 7 1999

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Sodium alginate
Tissue regeneration
Calcium Chloride
Calcium chloride
Alginate
Bone
Membranes
Defects
alginic acid
Surgery
Rats
Animals
Tissue

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Self-setting barrier membrane for guided tissue regeneration method : Initial evaluation of alginate membrane made with sodium alginate and calcium chloride aqueous solutions. / Ishikawa, Kunio; Ueyama, Yoshiya; Mano, Takamitsu; Koyama, Takahiro; Suzuki, Kazuomi; Matsumura, Tomohiro.

In: Journal of Biomedical Materials Research, Vol. 47, No. 2, 07.09.1999, p. 111-115.

Research output: Contribution to journalArticle

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