TY - JOUR
T1 - Self‐reactive T cells are activated by the 65‐kDa mycobacterial heat‐shock protein in neonatally thymectomized mice
AU - Iwasaki, Akinori
AU - Yoshikai, Yasunobu
AU - Yuuki, Hiroyuki
AU - Takimoto, Hiroaki
AU - Nomoto, Kikuo
PY - 1991/1/1
Y1 - 1991/1/1
N2 - To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self‐reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing Vβ11‐gene products capable of recognizing I‐E‐encoded molecules were readily detected in the mature T cell pool of NTX BALB/c (I‐Ed, Mls‐2a) mice. The Vβ11‐bearing T cells in NTX mice expressed interleukin 2 receptors and responded normally to signals delivered through the T cell receptor. Notably, these T cells in NTX mice proliferated significantly after culture with the 65‐kDa mycobacterial heat‐shock protein, whose amino acid sequence is highly homologous to that in eukaryotes. These results suggest that self‐reactive T cells in NTX mice may be activated by heat‐shock proteins derived from various pathogens and/or stressed autologous cells, resulting in the development of autoimmune diseases in such animals.
AB - To elucidate the mechanism of autoimmune disease in neonatally thymectomized (NTX) mice, we have investigated the responsiveness of the self‐reactive T cells which have not undergone clonal deletion in such animals. Consistent with a recent report (Yuuki et al., Eur. J. Immunol. 1990. 20: 1475), T cells bearing Vβ11‐gene products capable of recognizing I‐E‐encoded molecules were readily detected in the mature T cell pool of NTX BALB/c (I‐Ed, Mls‐2a) mice. The Vβ11‐bearing T cells in NTX mice expressed interleukin 2 receptors and responded normally to signals delivered through the T cell receptor. Notably, these T cells in NTX mice proliferated significantly after culture with the 65‐kDa mycobacterial heat‐shock protein, whose amino acid sequence is highly homologous to that in eukaryotes. These results suggest that self‐reactive T cells in NTX mice may be activated by heat‐shock proteins derived from various pathogens and/or stressed autologous cells, resulting in the development of autoimmune diseases in such animals.
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U2 - 10.1002/eji.1830210310
DO - 10.1002/eji.1830210310
M3 - Article
C2 - 1826260
AN - SCOPUS:0026065851
VL - 21
SP - 597
EP - 603
JO - European Journal of Immunology
JF - European Journal of Immunology
SN - 0014-2980
IS - 3
ER -