Semipermeable polymer vesicle 'PICsome' encapsulating biomacromolecules

A. Koide, Akihiro Kishimura, K. Osada, Y. Yamasaki, K. Kataoka

Research output: Contribution to conferencePaper

Abstract

A novel entity of a polymer vesicle, a PICsome, was prepared hers by simple mixing of a pair of oppositely charged block copolymers composed of biocompatible PEG and poly(amino acid)s in an aqueous medium. Confocal laser scanning microscopic observation further revealed the smooth penetration of a low molecular weight fluorescent dye (TRTTC; MW=443.5) emitting red fluorescence into the FITC-dextran encapsulated PICsome to give the PICsome image with a merged color of yellows, indicating the semipermeable nature of the PICsome membrane. The PICsomes showed appreciable physiological stability even in the presence of serum proteins, suggesting their feasibility in biomedical fields such as carriers of therapeutic compounds and compartments for diagnostic enzymes. These biocompatible composition and biologically-relevant characteristics of the PICsomes may open their future utility in biomedical fields such as carriers of therapeutic compounds and compartments for diagnostic enzymes.

Original languageEnglish
Pages4987-4988
Number of pages2
Publication statusPublished - Dec 1 2006
Externally publishedYes
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Other

Other55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Koide, A., Kishimura, A., Osada, K., Yamasaki, Y., & Kataoka, K. (2006). Semipermeable polymer vesicle 'PICsome' encapsulating biomacromolecules. 4987-4988. Paper presented at 55th Society of Polymer Science Japan Symposium on Macromolecules, Toyama, Japan.