TY - CHAP
T1 - Sendai virus for cancer immunotherapy
AU - Ueda, Yasuji
AU - Hasegawa, Mamoru
AU - Yonemitsu, Yoshikazu
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Dendritic cells (DCs) have a crucial role to play in fighting nonself organisms and cells, including tumors. Clinically, numerous DC vaccinations have been attempted for cancer immunotherapy since the first trial, published in 1995, but with limited success. We found that Sendai virus (SeV) vector infection induces maturation of DCs and produces more powerful antitumor immunity against DCs in mouse models. We used a SeV vector as an immune booster for tumors and believe that this novel therapy, designated as immunostimulatory virotherapy, will offer potent treatment for tumors.
AB - Dendritic cells (DCs) have a crucial role to play in fighting nonself organisms and cells, including tumors. Clinically, numerous DC vaccinations have been attempted for cancer immunotherapy since the first trial, published in 1995, but with limited success. We found that Sendai virus (SeV) vector infection induces maturation of DCs and produces more powerful antitumor immunity against DCs in mouse models. We used a SeV vector as an immune booster for tumors and believe that this novel therapy, designated as immunostimulatory virotherapy, will offer potent treatment for tumors.
UR - http://www.scopus.com/inward/record.url?scp=65649117375&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=65649117375&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-559-6_21
DO - 10.1007/978-1-59745-559-6_21
M3 - Chapter
C2 - 19378123
AN - SCOPUS:65649117375
SN - 9781934115879
T3 - Methods in Molecular Biology
SP - 299
EP - 308
BT - Viral Applications of Green Fluorescent Protein
PB - Humana Press Inc.
ER -
