TY - JOUR
T1 - Sensing the difference
T2 - The influence of anisotropic cues on cell behavior
AU - Ballester-Beltrán, José
AU - Biggs, Manus J.P.
AU - Dalby, Matthew J.
AU - Salmerón-Sánchez, Manuel
AU - Leal-Egaña, Aldo
N1 - Funding Information:
This work was supported by MRC grant MR/L022710/1 “synergistic microenvironments for non-union bone defects.”.
Funding Information:
This work was supported by MRC grant MR/L022710/1 “synergistic microenvironments for non-union bone defects.”
Publisher Copyright:
© 2015 Ballester-Beltrán, Biggs, Dalby, Salmerón-Sánchez and Leal-Egaña.
PY - 2015/5/8
Y1 - 2015/5/8
N2 - From tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical, and biological cues commonly presented in gradients. In this article, we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients in vitro. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g., ventral/dorsal anisotropy).
AB - From tissue morphogenesis to homeostasis, cells continuously experience and respond to physical, chemical, and biological cues commonly presented in gradients. In this article, we focus our discussion on the importance of nano/micro topographic cues on cell activity, and the role of anisotropic milieus play on cell behavior, mostly adhesion and migration. We present the need to study physiological gradients in vitro. To do this, we review different cell migration mechanisms and how adherent cells react to the presence of complex tissue-like environments and cell-surface stimulation in 2D and 3D (e.g., ventral/dorsal anisotropy).
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U2 - 10.3389/fmats.2015.00039
DO - 10.3389/fmats.2015.00039
M3 - Review article
AN - SCOPUS:85033706093
SN - 2296-8016
VL - 2
JO - Frontiers in Materials
JF - Frontiers in Materials
M1 - 39
ER -