TY - JOUR
T1 - Sensitivity Improvement of Magnetic Nanoparticle Imaging by Compensation with Digital-to-Analog Converter
AU - Sasayama, Teruyoshi
AU - Okamura, Naoki
AU - Yoshida, Takashi
N1 - Funding Information:
ACKNOWLEDGMENT The authors thank David MacDonald, MSc, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript. This work was supported in part by the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Young Scientists under Grant JP19K14996 and in part by a research grant from The Mazda Foundation.
Publisher Copyright:
© 1965-2012 IEEE.
PY - 2021/2
Y1 - 2021/2
N2 - In the application of the magnetic nanoparticle (MNP) imaging technique, which uses a large ac magnetic field and detects harmonic signals, it is important to attenuate the fundamental signal generated by the magnetic field used for excitation. In this article, we propose a method to reduce this fundamental signal using a compensation circuit with a digital-to-analog (D/A) converter, which can be interpreted as an electrical bridge. We apply the proposed method to an MNP imaging system. The system contains one excitation coil that generates an ac magnetic field and 16 pickup coils that detect the third-harmonic signals from the MNP samples. The position of an MNP sample containing 100 μg of Fe was estimated using this system via an inverse problem analysis. The results demonstrate that the fundamental signal is suppressed successfully and also show that the distance between the estimated and actual positions of the MNP sample is less than 10 mm at a depth of 50 mm.
AB - In the application of the magnetic nanoparticle (MNP) imaging technique, which uses a large ac magnetic field and detects harmonic signals, it is important to attenuate the fundamental signal generated by the magnetic field used for excitation. In this article, we propose a method to reduce this fundamental signal using a compensation circuit with a digital-to-analog (D/A) converter, which can be interpreted as an electrical bridge. We apply the proposed method to an MNP imaging system. The system contains one excitation coil that generates an ac magnetic field and 16 pickup coils that detect the third-harmonic signals from the MNP samples. The position of an MNP sample containing 100 μg of Fe was estimated using this system via an inverse problem analysis. The results demonstrate that the fundamental signal is suppressed successfully and also show that the distance between the estimated and actual positions of the MNP sample is less than 10 mm at a depth of 50 mm.
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U2 - 10.1109/TMAG.2020.3014375
DO - 10.1109/TMAG.2020.3014375
M3 - Article
AN - SCOPUS:85099550630
SN - 0018-9464
VL - 57
JO - IEEE Transactions on Magnetics
JF - IEEE Transactions on Magnetics
IS - 2
M1 - 9159546
ER -