Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

Masaru Mukai, Yuji Higaki, Tomoyasu Hirai, Atsushi Takahara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

Original languageEnglish
Pages (from-to)1509-1511
Number of pages3
JournalChemistry Letters
Volume47
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Phosphorylcholine
Anions
Byproducts
Column chromatography
Free radical polymerization
Polymers
Phosphates

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach. / Mukai, Masaru; Higaki, Yuji; Hirai, Tomoyasu; Takahara, Atsushi.

In: Chemistry Letters, Vol. 47, No. 12, 01.01.2018, p. 1509-1511.

Research output: Contribution to journalArticle

Mukai, Masaru ; Higaki, Yuji ; Hirai, Tomoyasu ; Takahara, Atsushi. / Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach. In: Chemistry Letters. 2018 ; Vol. 47, No. 12. pp. 1509-1511.
@article{b19fb230fef641968214e7492ab95062,
title = "Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach",
abstract = "2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.",
author = "Masaru Mukai and Yuji Higaki and Tomoyasu Hirai and Atsushi Takahara",
year = "2018",
month = "1",
day = "1",
doi = "10.1246/cl.180787",
language = "English",
volume = "47",
pages = "1509--1511",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "The Chemical Society of Japan",
number = "12",

}

TY - JOUR

T1 - Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

AU - Mukai, Masaru

AU - Higaki, Yuji

AU - Hirai, Tomoyasu

AU - Takahara, Atsushi

PY - 2018/1/1

Y1 - 2018/1/1

N2 - 2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

AB - 2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

UR - http://www.scopus.com/inward/record.url?scp=85057163889&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057163889&partnerID=8YFLogxK

U2 - 10.1246/cl.180787

DO - 10.1246/cl.180787

M3 - Article

AN - SCOPUS:85057163889

VL - 47

SP - 1509

EP - 1511

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 12

ER -