Separation of endo-cyclic 2-methacryloyloxyethyl choline phosphate by anion exchange approach

Masaru Mukai, Yuji Higaki, Tomoyasu Hirai, Atsushi Takahara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

2-Methacryloyloxyethyl choline phosphate (MCP) was synthesized by a ring-opening reaction of cyclic phosphates with 2-(dimethylaminoethyl methacrylate). The crude MCP consisted of an endo-cyclic desired product and an exo-cyclic byproduct. The exo-cyclic byproduct was completely removed by anion-exchange and subsequent open-column chromatography. We successfully obtained pure MCP without the exo-cyclic byproduct, and synthesized MCP polymers by free radical polymerization.

Original languageEnglish
Pages (from-to)1509-1511
Number of pages3
JournalChemistry Letters
Volume47
Issue number12
DOIs
Publication statusPublished - Jan 1 2018

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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