Separation of viable cells using deterministic lateral displacement microfluidic device

Naotomo Tottori, Jongho Park, Yasuko Yanagida, Takeshi Hatsuzawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report the first use of deterministic lateral displacement (DLD) microfluidic device for label-free separation of viable cells from nonviable cells. Cells in apoptosis status are physically smaller than viable cells. We focused on this phenomenon and have demonstrated the separation of viable cells from nonviable cells using DLD method, which can separate particles based on their sizes continuously without any labeling and external energy sources. We succeeded in the removal of 66.9% nonviable cells and also enrichment of viable cells.

Original languageEnglish
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages404-406
Number of pages3
ISBN (Electronic)9780979806483
Publication statusPublished - Jan 1 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Tottori, N., Park, J., Yanagida, Y., & Hatsuzawa, T. (2015). Separation of viable cells using deterministic lateral displacement microfluidic device. In MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 404-406). (MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences). Chemical and Biological Microsystems Society.