Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Yasunobu Yoshikai, Demetri Anatoniou, Stephen P. Clark, Yusuke Yanagi, Robert Sangster, Peter Van Den Elsen, Cox Terhorst, Tak W. Mak

    Research output: Contribution to journalArticlepeer-review

    283 Citations (Scopus)

    Abstract

    T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

    Original languageEnglish
    Pages (from-to)521-524
    Number of pages4
    JournalNature
    Volume312
    Issue number5994
    DOIs
    Publication statusPublished - 1984

    All Science Journal Classification (ASJC) codes

    • General

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