Sequence and expression of transcripts of the human T-cell receptor β- chain genes

Yasunobu Yoshikai, Demetri Anatoniou, Stephen P. Clark, Yusuke Yanagi, Robert Sangster, Peter Van Den Elsen, Cox Terhorst, Tak W. Mak

    Research output: Contribution to journalArticle

    279 Citations (Scopus)

    Abstract

    T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor β-chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

    Original languageEnglish
    Pages (from-to)521-524
    Number of pages4
    JournalNature
    Volume312
    Issue number5994
    DOIs
    Publication statusPublished - Dec 1 1984

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    T-Cell Receptor Genes
    T-Lymphocytes
    Messenger RNA
    Theophylline
    T-Cell Antigen Receptor
    Proteins

    All Science Journal Classification (ASJC) codes

    • General

    Cite this

    Yoshikai, Y., Anatoniou, D., Clark, S. P., Yanagi, Y., Sangster, R., Van Den Elsen, P., ... Mak, T. W. (1984). Sequence and expression of transcripts of the human T-cell receptor β- chain genes. Nature, 312(5994), 521-524. https://doi.org/10.1038/312521a0

    Sequence and expression of transcripts of the human T-cell receptor β- chain genes. / Yoshikai, Yasunobu; Anatoniou, Demetri; Clark, Stephen P.; Yanagi, Yusuke; Sangster, Robert; Van Den Elsen, Peter; Terhorst, Cox; Mak, Tak W.

    In: Nature, Vol. 312, No. 5994, 01.12.1984, p. 521-524.

    Research output: Contribution to journalArticle

    Yoshikai, Y, Anatoniou, D, Clark, SP, Yanagi, Y, Sangster, R, Van Den Elsen, P, Terhorst, C & Mak, TW 1984, 'Sequence and expression of transcripts of the human T-cell receptor β- chain genes', Nature, vol. 312, no. 5994, pp. 521-524. https://doi.org/10.1038/312521a0
    Yoshikai Y, Anatoniou D, Clark SP, Yanagi Y, Sangster R, Van Den Elsen P et al. Sequence and expression of transcripts of the human T-cell receptor β- chain genes. Nature. 1984 Dec 1;312(5994):521-524. https://doi.org/10.1038/312521a0
    Yoshikai, Yasunobu ; Anatoniou, Demetri ; Clark, Stephen P. ; Yanagi, Yusuke ; Sangster, Robert ; Van Den Elsen, Peter ; Terhorst, Cox ; Mak, Tak W. / Sequence and expression of transcripts of the human T-cell receptor β- chain genes. In: Nature. 1984 ; Vol. 312, No. 5994. pp. 521-524.
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