Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7

Reiko Kato, Hisao Shirohzu, Takaaki Yokomine, Shin Ichi Mizuno, Tsunehiro Mukai, Hiroyuki Sasaki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We have constructed approximately 1-Mb contigs of yeast artificial chromosome (YAC), bacterial artificial chromosome (BAC) and cosmid clones covering the imprinted region in mouse chromosome band 7F4/F5. This region is syntenic to human chromosome 11p15.5, which is associated with Beckwith-Wiedemann syndrome (BWS) and certain childhood and adult tumors. These contigs provide the basis for genomic sequencing, identification of genes and their regulatory elements, and functional studies in transgenic and knockout mice, which should be of help to understand not only the mechanisms of imprinting but also the molecular events involved in the genesis of BWS and tumors.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalDNA Research
Volume6
Issue number6
DOIs
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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