Sequential change of virus markers in seroconverters with community-acquired infection of human T lymphotropic virus type I

Akihiko Okayama, Sherri Stuver, Mutsunori Iga, Masayuki Okamoto, Nancy Mueller, Masao Matsuoka, Kazunari Yamaguchi, Nobuyoshi Tachibana, Hirohito Tsubouchi

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17 Citations (Scopus)

Abstract

Twenty-three human T lymphotropic virus type I (HTLV-I) seroconverters were identified among 1120 HTLV-I-seronegative adults followed up for 11 years in an area of Japan endemic for HTLV-I. The geometric mean titer of anti-HTLV-I was 1:453 in the first year after seroconversion; the titer of each subject did not change significantly during 2-10 years of follow-up. HTLV-I proviral DNA load was quantified in 15 seroconverters, and a broad range of levels was observed - from <10 to >1000 copies/105peripheral blood mononuclear cells. However, there was no obvious change in HTLV-I proviral DNA load over several years within individual subjects. Therefore, both proviral DNA load and humoral response in adult HTLV-I seroconverters were shown to stabilize within a few years after initial infection. In addition, 1 subject tested positive for HTLV-I proviral DNA before antibody seroconversion, which suggests the existence of a window period in community-acquired infection.

Original languageEnglish
Pages (from-to)1031-1037
Number of pages7
JournalJournal of Infectious Diseases
Volume183
Issue number7
DOIs
Publication statusPublished - Apr 1 2001

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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