TY - JOUR
T1 - Sequential change of virus markers in seroconverters with community-acquired infection of human T lymphotropic virus type I
AU - Okayama, Akihiko
AU - Stuver, Sherri
AU - Iga, Mutsunori
AU - Okamoto, Masayuki
AU - Mueller, Nancy
AU - Matsuoka, Masao
AU - Yamaguchi, Kazunari
AU - Tachibana, Nobuyoshi
AU - Tsubouchi, Hirohito
N1 - Funding Information:
Received 20 September 2000; revised 18 December 2000; electronically published 28 February 2001. Presented in part: 8th International Conference on Human Retrovirology: HTLV, Rio de Janeiro, Brazil, 1997 (abstract ED78). Informed consent was obtained from all study subjects. The studyprotocol was approved by human subjects committees of Miyazaki Medical College and Harvard School of Public Health. Financial support: National Institutes of Health (CA-38450); Ministry of Education, Science, Sports and Culture, Japan. a Present affiliation: Laboratory of Virus Immunology, Research Center for AIDS, Institute for Virus Research, Kyoto University, Kyoto, Japan. Reprints or correspondence: Dr. Akihiko Okayama, Dept. of Internal Medicine II, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 8891601, Japan (okayama@post1.miyazaki-med.ac.jp).
PY - 2001/4/1
Y1 - 2001/4/1
N2 - Twenty-three human T lymphotropic virus type I (HTLV-I) seroconverters were identified among 1120 HTLV-I-seronegative adults followed up for 11 years in an area of Japan endemic for HTLV-I. The geometric mean titer of anti-HTLV-I was 1:453 in the first year after seroconversion; the titer of each subject did not change significantly during 2-10 years of follow-up. HTLV-I proviral DNA load was quantified in 15 seroconverters, and a broad range of levels was observed - from <10 to >1000 copies/105peripheral blood mononuclear cells. However, there was no obvious change in HTLV-I proviral DNA load over several years within individual subjects. Therefore, both proviral DNA load and humoral response in adult HTLV-I seroconverters were shown to stabilize within a few years after initial infection. In addition, 1 subject tested positive for HTLV-I proviral DNA before antibody seroconversion, which suggests the existence of a window period in community-acquired infection.
AB - Twenty-three human T lymphotropic virus type I (HTLV-I) seroconverters were identified among 1120 HTLV-I-seronegative adults followed up for 11 years in an area of Japan endemic for HTLV-I. The geometric mean titer of anti-HTLV-I was 1:453 in the first year after seroconversion; the titer of each subject did not change significantly during 2-10 years of follow-up. HTLV-I proviral DNA load was quantified in 15 seroconverters, and a broad range of levels was observed - from <10 to >1000 copies/105peripheral blood mononuclear cells. However, there was no obvious change in HTLV-I proviral DNA load over several years within individual subjects. Therefore, both proviral DNA load and humoral response in adult HTLV-I seroconverters were shown to stabilize within a few years after initial infection. In addition, 1 subject tested positive for HTLV-I proviral DNA before antibody seroconversion, which suggests the existence of a window period in community-acquired infection.
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U2 - 10.1086/319282
DO - 10.1086/319282
M3 - Article
C2 - 11237827
AN - SCOPUS:0035312991
SN - 0022-1899
VL - 183
SP - 1031
EP - 1037
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -
