Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele

Chiaki Tanaka, Junichi Tanaka, Robert F. Bolland, Gerard Marriott, Tatsuo Higa

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Abstract

Six new depsipeptides, seragamides A-F (1-6), and a known geodiamolide I (7) have been isolated as cytotoxic metabolites from the Okinawan sponge Suberites japonicus. Their structures were elucidated by means of spectroscopic analysis and chemical transformations. Seragamide A (1) promotes the polymerization of G-actin and stabilizes F-actin filaments.

Original languageEnglish
Pages (from-to)3536-3542
Number of pages7
JournalTetrahedron
Volume62
Issue number15
DOIs
Publication statusPublished - Apr 10 2006
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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