Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele

Chiaki Tanaka; Junichi Tanaka; Robert F. Bolland; Gerard Marriott; Tatsuo Higa

doi:10.1016/j.tet.2006.01.099

Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele

Chiaki Tanaka, Junichi Tanaka, Robert F. Bolland, Gerard Marriott, Tatsuo Higa

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

Six new depsipeptides, seragamides A-F (1-6), and a known geodiamolide I (7) have been isolated as cytotoxic metabolites from the Okinawan sponge Suberites japonicus. Their structures were elucidated by means of spectroscopic analysis and chemical transformations. Seragamide A (1) promotes the polymerization of G-actin and stabilizes F-actin filaments.

Original language	English
Pages (from-to)	3536-3542
Number of pages	7
Journal	Tetrahedron
Volume	62
Issue number	15
DOIs	https://doi.org/10.1016/j.tet.2006.01.099
Publication status	Published - Apr 10 2006
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

Cite this

Tanaka, C., Tanaka, J., Bolland, R. F., Marriott, G., & Higa, T. (2006). Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele. Tetrahedron, 62(15), 3536-3542. https://doi.org/10.1016/j.tet.2006.01.099

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10.1016/j.tet.2006.01.099