@article{0d963bf31c3f466fa1733041bb798d9a,
title = "Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele",
abstract = "Six new depsipeptides, seragamides A-F (1-6), and a known geodiamolide I (7) have been isolated as cytotoxic metabolites from the Okinawan sponge Suberites japonicus. Their structures were elucidated by means of spectroscopic analysis and chemical transformations. Seragamide A (1) promotes the polymerization of G-actin and stabilizes F-actin filaments.",
author = "Chiaki Tanaka and Junichi Tanaka and Bolland, {Robert F.} and Gerard Marriott and Tatsuo Higa",
note = "Funding Information: This research was supported by a grant from The Cabinet Office of Japan through Research Institute for Subtropics in Okinawa, a grant titled as 21st century COE program: the Comprehensive Analyses on Biodiversity in Coral Reef and Island Ecosystems in Asian and Pacific Regions, a grant (No. 16550145) from MEXT of Japan, and a grant NIH R01 HL069970-01 to G.M. We thank Dr. T. Ichiba, Okinawa Industrial Technology Center, for mass measurements, and Dr. Hideo Naoki, Okinawa Health Biotechnology Research Development Center, for allowing us to use a fluorometer.",
year = "2006",
month = apr,
day = "10",
doi = "10.1016/j.tet.2006.01.099",
language = "English",
volume = "62",
pages = "3536--3542",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "15",
}