Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri LiMatthew G. Vander Heiden, Mieke Dewerchin, Peter Carmeliet

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Vandekeere et al. highlight a unique role for serine metabolism in endothelial cells (ECs). ECs utilize the serine synthetic pathway (SSP) differently from cancer cells and rely exclusively on the SSP for heme synthesis to maintain mitochondrial respiration and homeostasis.

Original languageEnglish
Pages (from-to)in press
JournalCell Metabolism
Volume28
Issue number4
Early online dateJul 12 2018
DOIs
Publication statusE-pub ahead of print - Jul 12 2018

Fingerprint

Heme
Serine
Endothelial Cells
Respiration
Homeostasis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M. R., García-Caballero, M., Goveia, J., ... Carmeliet, P. (2018). Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metabolism, 28(4), in press. https://doi.org/10.1016/j.cmet.2018.06.009

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. / Vandekeere, Saar; Dubois, Charlotte; Kalucka, Joanna; Sullivan, Mark R.; García-Caballero, Melissa; Goveia, Jermaine; Chen, Rongyuan; Diehl, Frances F.; Bar-Lev, Libat; Souffreau, Joris; Pircher, Andreas; Kumar, Saran; Vinckier, Stefan; Hirabayashi, Yoshio; Furuya, Shigeki; Schoonjans, Luc; Eelen, Guy; Ghesquière, Bart; Keshet, Eli; Li, Xuri; Vander Heiden, Matthew G.; Dewerchin, Mieke; Carmeliet, Peter.

In: Cell Metabolism, Vol. 28, No. 4, 12.07.2018, p. in press.

Research output: Contribution to journalArticle

Vandekeere, S, Dubois, C, Kalucka, J, Sullivan, MR, García-Caballero, M, Goveia, J, Chen, R, Diehl, FF, Bar-Lev, L, Souffreau, J, Pircher, A, Kumar, S, Vinckier, S, Hirabayashi, Y, Furuya, S, Schoonjans, L, Eelen, G, Ghesquière, B, Keshet, E, Li, X, Vander Heiden, MG, Dewerchin, M & Carmeliet, P 2018, 'Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells', Cell Metabolism, vol. 28, no. 4, pp. in press. https://doi.org/10.1016/j.cmet.2018.06.009
Vandekeere S, Dubois C, Kalucka J, Sullivan MR, García-Caballero M, Goveia J et al. Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metabolism. 2018 Jul 12;28(4):in press. https://doi.org/10.1016/j.cmet.2018.06.009
Vandekeere, Saar ; Dubois, Charlotte ; Kalucka, Joanna ; Sullivan, Mark R. ; García-Caballero, Melissa ; Goveia, Jermaine ; Chen, Rongyuan ; Diehl, Frances F. ; Bar-Lev, Libat ; Souffreau, Joris ; Pircher, Andreas ; Kumar, Saran ; Vinckier, Stefan ; Hirabayashi, Yoshio ; Furuya, Shigeki ; Schoonjans, Luc ; Eelen, Guy ; Ghesquière, Bart ; Keshet, Eli ; Li, Xuri ; Vander Heiden, Matthew G. ; Dewerchin, Mieke ; Carmeliet, Peter. / Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. In: Cell Metabolism. 2018 ; Vol. 28, No. 4. pp. in press.
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