Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Saar Vandekeere; Charlotte Dubois; Joanna Kalucka; Mark R. Sullivan; Melissa García-Caballero; Jermaine Goveia; Rongyuan Chen; Frances F. Diehl; Libat Bar-Lev; Joris Souffreau; Andreas Pircher; Saran Kumar; Stefan Vinckier; Yoshio Hirabayashi; Shigeki Furuya; Luc Schoonjans; Guy Eelen; Bart Ghesquière; Eli Keshet; Xuri Li; Matthew G. Vander Heiden; Mieke Dewerchin; Peter Carmeliet

doi:10.1016/j.cmet.2018.06.009

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

Saar Vandekeere, Charlotte Dubois, Joanna Kalucka, Mark R. Sullivan, Melissa García-Caballero, Jermaine Goveia, Rongyuan Chen, Frances F. Diehl, Libat Bar-Lev, Joris Souffreau, Andreas Pircher, Saran Kumar, Stefan Vinckier, Yoshio Hirabayashi, Shigeki Furuya, Luc Schoonjans, Guy Eelen, Bart Ghesquière, Eli Keshet, Xuri LiMatthew G. Vander Heiden, Mieke Dewerchin, Peter Carmeliet

Systems Biology

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Vandekeere et al. highlight a unique role for serine metabolism in endothelial cells (ECs). ECs utilize the serine synthetic pathway (SSP) differently from cancer cells and rely exclusively on the SSP for heme synthesis to maintain mitochondrial respiration and homeostasis.

Original language	English
Pages (from-to)	in press
Journal	Cell Metabolism
Volume	28
Issue number	4
Early online date	Jul 12 2018
DOIs	https://doi.org/10.1016/j.cmet.2018.06.009
Publication status	E-pub ahead of print - Jul 12 2018

All Science Journal Classification (ASJC) codes

Physiology
Molecular Biology
Cell Biology

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Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M. R., García-Caballero, M., Goveia, J., Chen, R., Diehl, F. F., Bar-Lev, L., Souffreau, J., Pircher, A., Kumar, S., Vinckier, S., Hirabayashi, Y., Furuya, S., Schoonjans, L., Eelen, G., Ghesquière, B., Keshet, E., ... Carmeliet, P. (2018). Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. Cell Metabolism, 28(4), in press. https://doi.org/10.1016/j.cmet.2018.06.009

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. / Vandekeere, Saar; Dubois, Charlotte; Kalucka, Joanna; Sullivan, Mark R.; García-Caballero, Melissa; Goveia, Jermaine; Chen, Rongyuan; Diehl, Frances F.; Bar-Lev, Libat; Souffreau, Joris; Pircher, Andreas; Kumar, Saran; Vinckier, Stefan; Hirabayashi, Yoshio; Furuya, Shigeki; Schoonjans, Luc; Eelen, Guy; Ghesquière, Bart; Keshet, Eli; Li, Xuri; Vander Heiden, Matthew G.; Dewerchin, Mieke; Carmeliet, Peter.

In: Cell Metabolism, Vol. 28, No. 4, 12.07.2018, p. in press.

Research output: Contribution to journal › Article › peer-review

Vandekeere, S, Dubois, C, Kalucka, J, Sullivan, MR, García-Caballero, M, Goveia, J, Chen, R, Diehl, FF, Bar-Lev, L, Souffreau, J, Pircher, A, Kumar, S, Vinckier, S, Hirabayashi, Y, Furuya, S, Schoonjans, L, Eelen, G, Ghesquière, B, Keshet, E, Li, X, Vander Heiden, MG, Dewerchin, M & Carmeliet, P 2018, 'Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells', Cell Metabolism, vol. 28, no. 4, pp. in press. https://doi.org/10.1016/j.cmet.2018.06.009

Vandekeere, Saar ; Dubois, Charlotte ; Kalucka, Joanna ; Sullivan, Mark R. ; García-Caballero, Melissa ; Goveia, Jermaine ; Chen, Rongyuan ; Diehl, Frances F. ; Bar-Lev, Libat ; Souffreau, Joris ; Pircher, Andreas ; Kumar, Saran ; Vinckier, Stefan ; Hirabayashi, Yoshio ; Furuya, Shigeki ; Schoonjans, Luc ; Eelen, Guy ; Ghesquière, Bart ; Keshet, Eli ; Li, Xuri ; Vander Heiden, Matthew G. ; Dewerchin, Mieke ; Carmeliet, Peter. / Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. In: Cell Metabolism. 2018 ; Vol. 28, No. 4. pp. in press.

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