@article{34fd17afaa504811b565fe1495983478,
title = "Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells",
abstract = "Vandekeere et al. highlight a unique role for serine metabolism in endothelial cells (ECs). ECs utilize the serine synthetic pathway (SSP) differently from cancer cells and rely exclusively on the SSP for heme synthesis to maintain mitochondrial respiration and homeostasis.",
author = "Saar Vandekeere and Charlotte Dubois and Joanna Kalucka and Sullivan, {Mark R.} and Melissa Garc{\'i}a-Caballero and Jermaine Goveia and Rongyuan Chen and Diehl, {Frances F.} and Libat Bar-Lev and Joris Souffreau and Andreas Pircher and Saran Kumar and Stefan Vinckier and Yoshio Hirabayashi and Shigeki Furuya and Luc Schoonjans and Guy Eelen and Bart Ghesqui{\`e}re and Eli Keshet and Xuri Li and {Vander Heiden}, {Matthew G.} and Mieke Dewerchin and Peter Carmeliet",
note = "Funding Information: The authors thank S.-M. Fendt, J. Rabinowitz, and G. Ducker for discussion and advice. They also thank P. Fransen, C.E. Van Hove (University of Antwerp), L.C. Conradi, M. Parys, and L. Treps for help with experiments or graphical design. They also thank A. Van Nuffelen, K. Brepoels, W. Mertens, S. Wyns, M. Nijs, G. Dubois, P. Vanwesemael, and A. Acosta Sanchez for technical assistance; the Cell Imaging Core (KU Leuven); VIB Bio Imaging Core (Leuven Platform); and Departmental Metabolomics Expertise Center (MEC). The Leica DM 5500 microscope was provided by InfraMouse (KU Leuven-VIB) through a Hercules type 3 project (ZW09-03). S. Vandekeere, C.D., and J.K. are supported by the ?Fonds voor Wetenschappelijk Onderzoek? (FWO). F.F.D. and M.R.S. were supported by NIGMS (T32GM007287). M.G.V.H. is supported by SU2C, the Lustgarten Foundation, the NCI (R01CA201276 and R21CA198028), the Ludwig Center at MIT, the MIT Center for Precision Cancer Medicine, and HHMI (faculty scholars grant); X.L. by the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at the Sun Yat-Sen University, and the National Natural Science Foundation of China (81330021 and 81670855); M.D. by a grant from the FWO; and P.C. by a Belgian Science Policy grant (IUAP7/03), long-term structural Methusalem funding (Flemish Government), grants from the FWO, Foundation Against Cancer (grant no. 2012-175), and a European Research Council (ERC) Advanced Research grant (EU-ERC269073). Funding Information: The authors thank S.-M. Fendt, J. Rabinowitz, and G. Ducker for discussion and advice. They also thank P. Fransen, C.E. Van Hove (University of Antwerp), L.C. Conradi, M. Parys, and L. Treps for help with experiments or graphical design. They also thank A. Van Nuffelen, K. Brepoels, W. Mertens, S. Wyns, M. Nijs, G. Dubois, P. Vanwesemael, and A. Acosta Sanchez for technical assistance; the Cell Imaging Core (KU Leuven); VIB Bio Imaging Core (Leuven Platform); and Departmental Metabolomics Expertise Center (MEC). The Leica DM 5500 microscope was provided by InfraMouse (KU Leuven-VIB) through a Hercules type 3 project (ZW09-03). S. Vandekeere, C.D., and J.K. are supported by the “Fonds voor Wetenschappelijk Onderzoek” (FWO). F.F.D. and M.R.S. were supported by NIGMS (T32GM007287). M.G.V.H. is supported by SU2C, the Lustgarten Foundation, the NCI (R01CA201276 and R21CA198028), the Ludwig Center at MIT, the MIT Center for Precision Cancer Medicine, and HHMI (faculty scholars grant); X.L. by the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at the Sun Yat-Sen University, and the National Natural Science Foundation of China (81330021 and 81670855); M.D. by a grant from the FWO; and P.C. by a Belgian Science Policy grant (IUAP7/03), long-term structural Methusalem funding (Flemish Government), grants from the FWO, Foundation Against Cancer (grant no. 2012-175), and a European Research Council (ERC) Advanced Research grant (EU-ERC269073). Funding Information: The authors thank S.-M. Fendt, J. Rabinowitz, and G. Ducker for discussion and advice. They also thank P. Fransen, C.E. Van Hove (University of Antwerp), L.C. Conradi, M. Parys, and L. Treps for help with experiments or graphical design. They also thank A. Van Nuffelen, K. Brepoels, W. Mertens, S. Wyns, M. Nijs, G. Dubois, P. Vanwesemael, and A. Acosta Sanchez for technical assistance; the Cell Imaging Core (KU Leuven); VIB Bio Imaging Core (Leuven Platform); and Departmental Metabolomics Expertise Center (MEC). The Leica DM 5500 microscope was provided by InfraMouse (KU Leuven-VIB) through a Hercules type 3 project (ZW09-03). S. Vandekeere, C.D., and J.K. are supported by the “ Fonds voor Wetenschappelijk Onderzoek ” (FWO). F.F.D. and M.R.S. were supported by NIGMS ( T32GM007287 ). M.G.V.H. is supported by SU2C , the Lustgarten Foundation , the NCI ( R01CA201276 and R21CA198028 ), the Ludwig Center at MIT , the MIT Center for Precision Cancer Medicine , and HHMI (faculty scholars grant); X.L. by the State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at the Sun Yat-Sen University , and the National Natural Science Foundation of China ( 81330021 and 81670855 ); M.D. by a grant from the FWO; and P.C. by a Belgian Science Policy grant ( IUAP7/03 ), long-term structural Methusalem funding ( Flemish Government ), grants from the FWO, Foundation Against Cancer (grant no. 2012-175 ), and a European Research Council (ERC) Advanced Research grant ( EU-ERC269073 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = jul,
day = "12",
doi = "10.1016/j.cmet.2018.06.009",
language = "English",
volume = "28",
pages = "in press",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",
}
