TY - JOUR
T1 - Seroepidemiology of TT virus infection and relationship between genotype and liver damage
AU - Tanaka, Yoko
AU - Hayashi, Jun
AU - Ariyama, Iwao
AU - Furusyo, Norihiro
AU - Etoh, Yoshitaka
AU - Kashiwagi, Seizaburo
PY - 2000
Y1 - 2000
N2 - TT virus (TTV) has been identified in patients with posttransfusion hepatitis of unknown etiology and is thought to be a new hepatitis virus. We determined the extent of TTV infection in the Japanese general population and the relationship between TTV DNA genotype and liver damage. In 1998, we tested 847 serum samples for TTV. TTV DNA was assayed by a nested polymerase chain reaction and classified into three different genotypes and eight subtypes. TTV DNA was detected in 25.3% and 32.4% of the inhabitants of the two areas studied, respectively. The genotype distribution was similar in both areas. G1, G2, and G3 were 60%, 20%, and 5%, respectively. Of the 20 subjects with TTV DNA alone and elevated serum ALT levels, 18 were G1, one was G2, and one was G3. TTV infection is endemic in the Japanese general population studied. The main TTV genotype, G1, may be related to the ensuing liver damage.
AB - TT virus (TTV) has been identified in patients with posttransfusion hepatitis of unknown etiology and is thought to be a new hepatitis virus. We determined the extent of TTV infection in the Japanese general population and the relationship between TTV DNA genotype and liver damage. In 1998, we tested 847 serum samples for TTV. TTV DNA was assayed by a nested polymerase chain reaction and classified into three different genotypes and eight subtypes. TTV DNA was detected in 25.3% and 32.4% of the inhabitants of the two areas studied, respectively. The genotype distribution was similar in both areas. G1, G2, and G3 were 60%, 20%, and 5%, respectively. Of the 20 subjects with TTV DNA alone and elevated serum ALT levels, 18 were G1, one was G2, and one was G3. TTV infection is endemic in the Japanese general population studied. The main TTV genotype, G1, may be related to the ensuing liver damage.
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U2 - 10.1023/A:1026644704220
DO - 10.1023/A:1026644704220
M3 - Article
C2 - 11215742
AN - SCOPUS:0034527843
SN - 0163-2116
VL - 45
SP - 2214
EP - 2220
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 11
M1 - 293352
ER -
