Seroprevalence of Helicobacter pylori infection in Nepal: Low prevalence in an isolated rural village

Masumi Kawasaki, Terukazu Kawasaki, Tetsuro Ogaki, Kazue Itoh, Shigeru Kobayashi, Yutaka Yoshimizu, Kunihiko Aoyagi, Akiko Iwakawa, Shinsuke Takahashi, Sashi Sharma, Gopal P. Acharya

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19 Citations (Scopus)

Abstract

Objective. To determine the seroprevalence of Helicobacter pylori infection in Nepal. Design. H. pylori infection was identified using a specific and sensitive enzyme-linked immunosorbent assay for anti-H pylori immunoglobulin G. Study. population Serum samples were collected from 1142 inhabitants (age range 4-93 years) from two villages: Kotyang, a rural isolated village (250 men, 210 women) and Bhadrakali, a suburban village of Kathmandu (334 men, 348 women). Results. The overall prevalence of H. pylori infection was 56.8%, while a significantly higher prevalence was found in the suburban village (Bhadrakali; 67.2%) than in the rural village (Kotyang; 41.5%). This difference was generally reflected by the infection rate in the 10-14-year-old age-group (Bhadrakali, 60% compared with Kotyang, 22.2%). The prevalence of infection significantly increased with age, while no significant difference was found in the prevalence of infection by gender. There was no difference in H. pylori positivity between individuals with and without upper abdominal symptoms in both villages. Conclusion. There was a significant regional difference in the seroprevalence of H. pylori within Nepal, which showed lower prevalence in an isolated rural village. This difference was mainly caused by the different acquisition rate in teenagers, thus indicating that the teenage lifestyle of this particular environment seemed to be the major determinant in the acquisition of H. pylori infection in the population.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalEuropean Journal of Gastroenterology and Hepatology
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 1 1998

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Nepal
Seroepidemiologic Studies
Helicobacter Infections
Helicobacter pylori
Infection
Pylorus
Population
Life Style
Age Groups
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Seroprevalence of Helicobacter pylori infection in Nepal : Low prevalence in an isolated rural village. / Kawasaki, Masumi; Kawasaki, Terukazu; Ogaki, Tetsuro; Itoh, Kazue; Kobayashi, Shigeru; Yoshimizu, Yutaka; Aoyagi, Kunihiko; Iwakawa, Akiko; Takahashi, Shinsuke; Sharma, Sashi; Acharya, Gopal P.

In: European Journal of Gastroenterology and Hepatology, Vol. 10, No. 1, 01.01.1998, p. 47-50.

Research output: Contribution to journalArticle

Kawasaki, M, Kawasaki, T, Ogaki, T, Itoh, K, Kobayashi, S, Yoshimizu, Y, Aoyagi, K, Iwakawa, A, Takahashi, S, Sharma, S & Acharya, GP 1998, 'Seroprevalence of Helicobacter pylori infection in Nepal: Low prevalence in an isolated rural village', European Journal of Gastroenterology and Hepatology, vol. 10, no. 1, pp. 47-50. https://doi.org/10.1097/00042737-199801000-00009
Kawasaki, Masumi ; Kawasaki, Terukazu ; Ogaki, Tetsuro ; Itoh, Kazue ; Kobayashi, Shigeru ; Yoshimizu, Yutaka ; Aoyagi, Kunihiko ; Iwakawa, Akiko ; Takahashi, Shinsuke ; Sharma, Sashi ; Acharya, Gopal P. / Seroprevalence of Helicobacter pylori infection in Nepal : Low prevalence in an isolated rural village. In: European Journal of Gastroenterology and Hepatology. 1998 ; Vol. 10, No. 1. pp. 47-50.
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AU - Kobayashi, Shigeru

AU - Yoshimizu, Yutaka

AU - Aoyagi, Kunihiko

AU - Iwakawa, Akiko

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AU - Sharma, Sashi

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