Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks

Rong Lily Zhang, Tetsuya Tachibana, Tomo Takagi, Tomoyuki Koutoku, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and serotonin is one of the possible mechanisms through which GLP-1 affects CRF-induced behaviors. The present experiments were conducted to confirm the effect of serotonin on CRF-induced behaviors. In Experiment 1, chicks were intracerebroventricularly injected with either saline, 0.1μg of CRF, 5.0μg of serotonin, or 0.1μg of CRF plus 5.0μg of serotonin. Injection of CRF caused excitation as evidenced by increased spontaneous activities and distress vocalizations (DVs) compared to the control group. The effect of CRF was attenuated by serotonin since chicks became quiet after given CRF with serotonin. Sleep-like behaviors were observed in the serotonin group. The number of defecations was increased by CRF and decreased by serotonin. Both CRF and serotonin increased plasma corticosterone, and the effect was synergistic. Serotonin dose-dependently decreased locomotor activities of chicks after central administration of 0.1μg of CRF, 0.1μg of CRF plus 2.5, 5.0, or 10.0μg of serotonin in Experiment 2. CRF-induced DVs were modified by serotonin. Instead of DVs, tender and low-pitched vocalizations were observed in chicks treated with CRF plus serotonin, the voice frequencies of which were less than 10kHz. In conclusion, serotonin attenuated the CRF-induced behaviors while stimulating corticosterone release. These results indicate that the role of serotonin is dependent on the behaviors being measured.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalBehavioural Brain Research
Volume151
Issue number1-2
DOIs
Publication statusPublished - May 5 2004

Fingerprint

Corticotropin-Releasing Hormone
Serotonin
Glucagon-Like Peptide 1
Corticosterone
Defecation
Locomotion

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks. / Zhang, Rong Lily; Tachibana, Tetsuya; Takagi, Tomo; Koutoku, Tomoyuki; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Behavioural Brain Research, Vol. 151, No. 1-2, 05.05.2004, p. 47-52.

Research output: Contribution to journalArticle

Zhang, Rong Lily ; Tachibana, Tetsuya ; Takagi, Tomo ; Koutoku, Tomoyuki ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks. In: Behavioural Brain Research. 2004 ; Vol. 151, No. 1-2. pp. 47-52.
@article{2fe9790ed7754becac8e10917c4bd13f,
title = "Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks",
abstract = "Glucagon-like peptide-1 (GLP-1) decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and serotonin is one of the possible mechanisms through which GLP-1 affects CRF-induced behaviors. The present experiments were conducted to confirm the effect of serotonin on CRF-induced behaviors. In Experiment 1, chicks were intracerebroventricularly injected with either saline, 0.1μg of CRF, 5.0μg of serotonin, or 0.1μg of CRF plus 5.0μg of serotonin. Injection of CRF caused excitation as evidenced by increased spontaneous activities and distress vocalizations (DVs) compared to the control group. The effect of CRF was attenuated by serotonin since chicks became quiet after given CRF with serotonin. Sleep-like behaviors were observed in the serotonin group. The number of defecations was increased by CRF and decreased by serotonin. Both CRF and serotonin increased plasma corticosterone, and the effect was synergistic. Serotonin dose-dependently decreased locomotor activities of chicks after central administration of 0.1μg of CRF, 0.1μg of CRF plus 2.5, 5.0, or 10.0μg of serotonin in Experiment 2. CRF-induced DVs were modified by serotonin. Instead of DVs, tender and low-pitched vocalizations were observed in chicks treated with CRF plus serotonin, the voice frequencies of which were less than 10kHz. In conclusion, serotonin attenuated the CRF-induced behaviors while stimulating corticosterone release. These results indicate that the role of serotonin is dependent on the behaviors being measured.",
author = "Zhang, {Rong Lily} and Tetsuya Tachibana and Tomo Takagi and Tomoyuki Koutoku and Denbow, {D. Michael} and Mitsuhiro Furuse",
year = "2004",
month = "5",
day = "5",
doi = "10.1016/j.bbr.2003.08.005",
language = "English",
volume = "151",
pages = "47--52",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks

AU - Zhang, Rong Lily

AU - Tachibana, Tetsuya

AU - Takagi, Tomo

AU - Koutoku, Tomoyuki

AU - Denbow, D. Michael

AU - Furuse, Mitsuhiro

PY - 2004/5/5

Y1 - 2004/5/5

N2 - Glucagon-like peptide-1 (GLP-1) decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and serotonin is one of the possible mechanisms through which GLP-1 affects CRF-induced behaviors. The present experiments were conducted to confirm the effect of serotonin on CRF-induced behaviors. In Experiment 1, chicks were intracerebroventricularly injected with either saline, 0.1μg of CRF, 5.0μg of serotonin, or 0.1μg of CRF plus 5.0μg of serotonin. Injection of CRF caused excitation as evidenced by increased spontaneous activities and distress vocalizations (DVs) compared to the control group. The effect of CRF was attenuated by serotonin since chicks became quiet after given CRF with serotonin. Sleep-like behaviors were observed in the serotonin group. The number of defecations was increased by CRF and decreased by serotonin. Both CRF and serotonin increased plasma corticosterone, and the effect was synergistic. Serotonin dose-dependently decreased locomotor activities of chicks after central administration of 0.1μg of CRF, 0.1μg of CRF plus 2.5, 5.0, or 10.0μg of serotonin in Experiment 2. CRF-induced DVs were modified by serotonin. Instead of DVs, tender and low-pitched vocalizations were observed in chicks treated with CRF plus serotonin, the voice frequencies of which were less than 10kHz. In conclusion, serotonin attenuated the CRF-induced behaviors while stimulating corticosterone release. These results indicate that the role of serotonin is dependent on the behaviors being measured.

AB - Glucagon-like peptide-1 (GLP-1) decreased corticotropin-releasing factor (CRF)-induced behaviors in neonatal chicks, and serotonin is one of the possible mechanisms through which GLP-1 affects CRF-induced behaviors. The present experiments were conducted to confirm the effect of serotonin on CRF-induced behaviors. In Experiment 1, chicks were intracerebroventricularly injected with either saline, 0.1μg of CRF, 5.0μg of serotonin, or 0.1μg of CRF plus 5.0μg of serotonin. Injection of CRF caused excitation as evidenced by increased spontaneous activities and distress vocalizations (DVs) compared to the control group. The effect of CRF was attenuated by serotonin since chicks became quiet after given CRF with serotonin. Sleep-like behaviors were observed in the serotonin group. The number of defecations was increased by CRF and decreased by serotonin. Both CRF and serotonin increased plasma corticosterone, and the effect was synergistic. Serotonin dose-dependently decreased locomotor activities of chicks after central administration of 0.1μg of CRF, 0.1μg of CRF plus 2.5, 5.0, or 10.0μg of serotonin in Experiment 2. CRF-induced DVs were modified by serotonin. Instead of DVs, tender and low-pitched vocalizations were observed in chicks treated with CRF plus serotonin, the voice frequencies of which were less than 10kHz. In conclusion, serotonin attenuated the CRF-induced behaviors while stimulating corticosterone release. These results indicate that the role of serotonin is dependent on the behaviors being measured.

UR - http://www.scopus.com/inward/record.url?scp=16544367275&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16544367275&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2003.08.005

DO - 10.1016/j.bbr.2003.08.005

M3 - Article

C2 - 15084420

AN - SCOPUS:16544367275

VL - 151

SP - 47

EP - 52

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1-2

ER -