TY - JOUR
T1 - Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community
T2 - The hisayama study
AU - Izumaru, Kensuke
AU - Ninomiya, Toshiharu
AU - Nagata, Masaharu
AU - Usui, Tomoko
AU - Yoshida, Daigo
AU - Yonemoto, Koji
AU - Fukuhara, Masayo
AU - Tsuruya, Kazuhiko
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
PY - 2014
Y1 - 2014
N2 - Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60 ml · min-1 · 1.73 m-2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR 0.10ml · min-1 · 1.73m-2 · year-1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population.
AB - Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60 ml · min-1 · 1.73 m-2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR 0.10ml · min-1 · 1.73m-2 · year-1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population.
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U2 - 10.1253/circj.CJ-13-0422
DO - 10.1253/circj.CJ-13-0422
M3 - Article
C2 - 24351652
AN - SCOPUS:84894472852
VL - 78
SP - 732
EP - 737
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 3
ER -