Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community

The hisayama study

Kensuke Izumaru, Toshiharu Ninomiya, Masaharu Nagata, Tomoko Usui, Daigo Yoshida, Koji Yonemoto, Masayo Fukuhara, Kazuhiko Tsuruya, Takanari Kitazono, Yutaka Kiyohara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60 ml · min-1 · 1.73 m-2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR 0.10ml · min-1 · 1.73m-2 · year-1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population.

Original languageEnglish
Pages (from-to)732-737
Number of pages6
JournalCirculation Journal
Volume78
Issue number3
DOIs
Publication statusPublished - Jan 1 2014

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Chronic Renal Insufficiency
Kidney
Serum
Glomerular Filtration Rate
Vitamin D Deficiency
Independent Living
Incidence
Population
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community : The hisayama study. / Izumaru, Kensuke; Ninomiya, Toshiharu; Nagata, Masaharu; Usui, Tomoko; Yoshida, Daigo; Yonemoto, Koji; Fukuhara, Masayo; Tsuruya, Kazuhiko; Kitazono, Takanari; Kiyohara, Yutaka.

In: Circulation Journal, Vol. 78, No. 3, 01.01.2014, p. 732-737.

Research output: Contribution to journalArticle

Izumaru, Kensuke ; Ninomiya, Toshiharu ; Nagata, Masaharu ; Usui, Tomoko ; Yoshida, Daigo ; Yonemoto, Koji ; Fukuhara, Masayo ; Tsuruya, Kazuhiko ; Kitazono, Takanari ; Kiyohara, Yutaka. / Serum 1,25-dihydroxyvitamin d and the development of kidney dysfunction in a Japanese community : The hisayama study. In: Circulation Journal. 2014 ; Vol. 78, No. 3. pp. 732-737.
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AU - Izumaru, Kensuke

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AU - Nagata, Masaharu

AU - Usui, Tomoko

AU - Yoshida, Daigo

AU - Yonemoto, Koji

AU - Fukuhara, Masayo

AU - Tsuruya, Kazuhiko

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

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N2 - Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60 ml · min-1 · 1.73 m-2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR 0.10ml · min-1 · 1.73m-2 · year-1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population.

AB - Background: Recent evidence indicates that vitamin D deficiency is associated with an increased risk of renal impairment, but studies addressing the influence of vitamin D deficiency on the development of chronic kidney disease (CKD) in the general Asian population have been few. Methods and Results: A total of 2,417 community-dwelling individuals without CKD stage 3-5 aged ≥40 years were followed for 5 years (mean age, 60 years; women, 59.1%). The cumulative incidence of CKD stage 3-5, defined as estimated glomerular filtration rate (eGFR) <60 ml · min-1 · 1.73 m-2, and the rate of decline in eGFR according to quartile of serum 1,25-dihydroxyvitamin D (1,25(OH)2D), were estimated. During follow-up, 378 subjects experienced CKD stage 3-5. The age- and sex-adjusted incidence of CKD stage 3-5 increased significantly with decreasing serum 1,25(OH)2D (P for trend <0.001). Compared with the highest quartile, the multivariate-adjusted odds ratio for the development of CKD stage 3-5 was 1.90 in the lowest quartile and 1.74 in the second lowest quartile, after adjusting for confounding factors. Additionally, lower serum 1,25(OH)2D was significantly associated with a greater change in eGFR 0.10ml · min-1 · 1.73m-2 · year-1 per 10-pg/ml decrement in serum 1,25(OH)2D). Conclusions: Lower serum 1,25(OH)2D is a significant risk factor for the development of CKD stage 3-5 in the general Asian population.

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