Serum 1,5-anhydro-D-glucitol and glycemic control in patients with non-insulin-dependent diabetes mellitus.

F. Umeda, T. Yamauchi, H. Ishii, Naoki Nakashima, A. Hisatomi, H. Nawata

Research output: Contribution to journalArticle

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Abstract

Serum 1,5-anhydro-D-glucitol (AG) levels, which have been reported to decrease specifically in diabetics, were measured in 102 patients with non-insulin-dependent diabetes mellitus (NIDDM). The mean of serum AG levels was 7.9 +/- 0.7 micrograms/ml (mean +/- S.E.). It was found a significant negative correlation between serum AG level and HbA1c or fasting blood sugar level. The decrease in serum AG levels inversely correlated with the extent of glycemic control in the patients with NIDDM. Additionally, the changes of serum AG levels negatively correlated with the changes of HbA1c levels during long-term (2 years) treatment. Furthermore, serum AG levels were compared between the patients with and without diabetic complication such as retinopathy, proteinuria or neuropathy. It was found that each group of the patients with complication had significantly decreased serum AG level compared with the complication free group. On the other hand, however, no differences were found in serum AG levels corrected by HbA1c levels using the linear regression formula between the group of the patients with and without diabetic complication.

Original languageEnglish
Pages (from-to)93-100
Number of pages8
JournalThe Tohoku journal of experimental medicine
Volume163
Issue number2
DOIs
Publication statusPublished - Jan 1 1991

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Medical problems
Type 2 Diabetes Mellitus
Serum
Diabetes Complications
1,5-anhydroglucitol
Proteinuria
Linear regression
Blood Glucose
Linear Models
Fasting

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Serum 1,5-anhydro-D-glucitol and glycemic control in patients with non-insulin-dependent diabetes mellitus. / Umeda, F.; Yamauchi, T.; Ishii, H.; Nakashima, Naoki; Hisatomi, A.; Nawata, H.

In: The Tohoku journal of experimental medicine, Vol. 163, No. 2, 01.01.1991, p. 93-100.

Research output: Contribution to journalArticle

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abstract = "Serum 1,5-anhydro-D-glucitol (AG) levels, which have been reported to decrease specifically in diabetics, were measured in 102 patients with non-insulin-dependent diabetes mellitus (NIDDM). The mean of serum AG levels was 7.9 +/- 0.7 micrograms/ml (mean +/- S.E.). It was found a significant negative correlation between serum AG level and HbA1c or fasting blood sugar level. The decrease in serum AG levels inversely correlated with the extent of glycemic control in the patients with NIDDM. Additionally, the changes of serum AG levels negatively correlated with the changes of HbA1c levels during long-term (2 years) treatment. Furthermore, serum AG levels were compared between the patients with and without diabetic complication such as retinopathy, proteinuria or neuropathy. It was found that each group of the patients with complication had significantly decreased serum AG level compared with the complication free group. On the other hand, however, no differences were found in serum AG levels corrected by HbA1c levels using the linear regression formula between the group of the patients with and without diabetic complication.",
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AU - Hisatomi, A.

AU - Nawata, H.

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