TY - JOUR
T1 - Serum albumin levels as an independent predictor of 4-year mortality in a community-dwelling 80-year-old population
AU - Takata, Yutaka
AU - Ansai, Toshihiro
AU - Soh, Inho
AU - Awano, Shuji
AU - Sonoki, Kazuo
AU - Akifusa, Sumio
AU - Kagiyama, Shuntaro
AU - Hamasaki, Tomoko
AU - Torisu, Takehiro
AU - Yoshida, Akihiro
AU - Nakamichi, Ikuo
AU - Takehara, Tadamichi
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (B) 18390570 (Y.T.), 15390655 (Y.T.), and Grants-in-Aid for Exploratory Research 20659330 (Y.T.), 17659663 (Y.T.) from the Japan Society for the Promotion of Science, and Grants (2008) from the 8020 Promotion Foundation.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2010/2
Y1 - 2010/2
N2 - Background and aims: Although serum albumin levels are associated with mortality in non-institutionalized elderly people under 80 years old, as well as in the institutionalized very elderly, little is known about the relationship in community-dwelling very elderly people. We, therefore, examined the association in a Japanese population of 80-year-old community residents. Methods: Serum albumin levels were measured in 672 (267 men, 405 women) out of 1282 80-year-old individuals. Over the following 4 years, the dates and causes of death were recorded from resident registration cards and official death certificates. Results: Of the above individuals, 107 subjects died (58 men, 49 women: 27 due to cancer, 27 cardiovascular disease, and 22 pneumonia). Survival rates were compared among 4 groups (highest ≥45 g/L, higher than 43-44 g/L, lower than 41-42 g/L, lowest ≤40 g/L). After adjustment for confounding factors, total death or cardiovascular death in the lowest albumin group was 3.1 times and 10.7 times more incident than in the highest albumin group, but there were no differences among groups as regards deaths due to cancer or pneumonia. Conclusion: Serum albumin levels are an independent predictor of mortality due to all-cause or cardiovascular disease, but not of mortality due to cancer or pneumonia in very elderly Japanese community residents.
AB - Background and aims: Although serum albumin levels are associated with mortality in non-institutionalized elderly people under 80 years old, as well as in the institutionalized very elderly, little is known about the relationship in community-dwelling very elderly people. We, therefore, examined the association in a Japanese population of 80-year-old community residents. Methods: Serum albumin levels were measured in 672 (267 men, 405 women) out of 1282 80-year-old individuals. Over the following 4 years, the dates and causes of death were recorded from resident registration cards and official death certificates. Results: Of the above individuals, 107 subjects died (58 men, 49 women: 27 due to cancer, 27 cardiovascular disease, and 22 pneumonia). Survival rates were compared among 4 groups (highest ≥45 g/L, higher than 43-44 g/L, lower than 41-42 g/L, lowest ≤40 g/L). After adjustment for confounding factors, total death or cardiovascular death in the lowest albumin group was 3.1 times and 10.7 times more incident than in the highest albumin group, but there were no differences among groups as regards deaths due to cancer or pneumonia. Conclusion: Serum albumin levels are an independent predictor of mortality due to all-cause or cardiovascular disease, but not of mortality due to cancer or pneumonia in very elderly Japanese community residents.
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U2 - 10.1007/BF03324812
DO - 10.1007/BF03324812
M3 - Article
C2 - 20305365
AN - SCOPUS:77951861818
SN - 1594-0667
VL - 22
SP - 31
EP - 35
JO - Aging clinical and experimental research
JF - Aging clinical and experimental research
IS - 1
ER -
