Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults

Kayo Kurotani, Masao Sato, Yuko Ejima, Kentaro Kashima, Akiko Nanri, Ngoc Minh Pham, Keisuke Kuwahara, Tetsuya Mizoue

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background & aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women. Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms. Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend=0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend=0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend=0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms. Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.

Original languageEnglish
Pages (from-to)e7-e12
Journale-SPEN Journal
Volume9
Issue number1
DOIs
Publication statusPublished - Feb 1 2014

Fingerprint

Linolenic Acids
Linoleic Acids
Depression
Serum
Fatty Acids
alpha-Linolenic Acid
Cholesterol Esters
Omega-3 Fatty Acids
Linoleic Acid
Unsaturated Fatty Acids
Gas Chromatography
Epidemiologic Studies
Phospholipids
Fishes
Cross-Sectional Studies
Logistic Models
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults. / Kurotani, Kayo; Sato, Masao; Ejima, Yuko; Kashima, Kentaro; Nanri, Akiko; Pham, Ngoc Minh; Kuwahara, Keisuke; Mizoue, Tetsuya.

In: e-SPEN Journal, Vol. 9, No. 1, 01.02.2014, p. e7-e12.

Research output: Contribution to journalArticle

Kurotani, K, Sato, M, Ejima, Y, Kashima, K, Nanri, A, Pham, NM, Kuwahara, K & Mizoue, T 2014, 'Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults', e-SPEN Journal, vol. 9, no. 1, pp. e7-e12. https://doi.org/10.1016/j.clnme.2013.12.003
Kurotani, Kayo ; Sato, Masao ; Ejima, Yuko ; Kashima, Kentaro ; Nanri, Akiko ; Pham, Ngoc Minh ; Kuwahara, Keisuke ; Mizoue, Tetsuya. / Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults. In: e-SPEN Journal. 2014 ; Vol. 9, No. 1. pp. e7-e12.
@article{f68b37c2986f448d91cc61f2ed971dc3,
title = "Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults",
abstract = "Background & aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women. Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms. Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend=0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95{\%} confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend=0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend=0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms. Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.",
author = "Kayo Kurotani and Masao Sato and Yuko Ejima and Kentaro Kashima and Akiko Nanri and Pham, {Ngoc Minh} and Keisuke Kuwahara and Tetsuya Mizoue",
year = "2014",
month = "2",
day = "1",
doi = "10.1016/j.clnme.2013.12.003",
language = "English",
volume = "9",
pages = "e7--e12",
journal = "e-SPEN",
issn = "2212-8263",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Serum alpha-linolenic and linoleic acids are inversely associated with depressive symptoms in adults

AU - Kurotani, Kayo

AU - Sato, Masao

AU - Ejima, Yuko

AU - Kashima, Kentaro

AU - Nanri, Akiko

AU - Pham, Ngoc Minh

AU - Kuwahara, Keisuke

AU - Mizoue, Tetsuya

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Background & aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women. Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms. Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend=0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend=0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend=0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms. Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.

AB - Background & aims: Fatty acid composition in diet and serum has been linked to depression, but the evidence on this issue is limited among Japanese, who consume large amounts of fish rich in n-3 polyunsaturated fatty acids. We examined the association between fatty acid composition in serum and depressive symptoms in Japanese men and women. Methods: The subjects were 496 participants aged 21-67 years in a cross-sectional study. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Free, cholesterol ester, and phospholipid fatty acids in serum were measured by gas-liquid chromatography. Multiple logistic regression was used to assess the association between serum fatty acid and depressive symptoms. Results: A higher free alpha-linolenic acid level was marginally significantly associated with a decreased prevalence of depressive symptoms (CES-D≥16) (P for trend=0.07). When a cut-off of CES-D≥19 was used, the association was strengthened; the multivariable-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest through highest tertile of alpha-linolenic acid levels were 1.00 (reference), 0.49 (0.29-0.84), and 0.47 (0.26-0.83), respectively (P for trend=0.007). A higher n-6 PUFA in cholesterol esters and free linoleic acid were also significantly associated with a decreased prevalence of depressive symptoms (CES-D≥19) (P for trend=0.03 and 0.048, respectively). The other polyunsaturated fatty acids including marine-derived n-3 PUFA were not associated with depressive symptoms. Conclusions: Fatty acid composition with high levels of serum alpha-linolenic and linoleic acids might be protectively associated with depressive symptoms in Japanese adults.

UR - http://www.scopus.com/inward/record.url?scp=84892957363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892957363&partnerID=8YFLogxK

U2 - 10.1016/j.clnme.2013.12.003

DO - 10.1016/j.clnme.2013.12.003

M3 - Article

AN - SCOPUS:84892957363

VL - 9

SP - e7-e12

JO - e-SPEN

JF - e-SPEN

SN - 2212-8263

IS - 1

ER -