Serum and urinary inorganic fluoride concentrations with renal and hepatic functions after repeated sevoflurane anesthesia

Tamie Takenami, Masayasu Arai, Shigeyuki Matsuzaki, Ken Anzai, Tetsuo Ueno, Sumio Hoka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The purpose of this study is to examine changes in serum and urinary inorganic fluoride (F) concentrations with their effects on renal and hepatic functions after repeated sevoflurane anesthesia with relatively short time interval. Eight patients received sevoflurane anesthesia twice within 7 days for gynecological surgery. Serum and urine F levels before induction, 0.5 and 1 hour after induction, and 0.5 hour after anesthesia were compared between first and second anesthesia. There were no significant differences in serum and urine F concentrations at the same point between first and second anesthesia. Two obese patients exhibited peak concentrations greater than 50 μmol·l-1 of F. Laboratory findings of renal function remained stable throughout 2 operations, whereas hepatic function deteriorated in the two obese patients after the first anesthesia, and resolved within 14 days after the second anesthesia. In conclusion, it is suggested that the second exposure to sevoflurane within 7 day interval does not alter the sevoflurane metabolism. However, obesity may contribute to a rise in serum inorganic fluoride after repeated sevoflurane anesthesia.

Original languageEnglish
Pages (from-to)1086-1093
Number of pages8
JournalJapanese Journal of Anesthesiology
Volume51
Issue number10
Publication statusPublished - Oct 1 2002
Externally publishedYes

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Fluorides
Anesthesia
Kidney
Liver
Serum
Urine
Gynecologic Surgical Procedures
sevoflurane
Ambulatory Surgical Procedures
Obesity

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Serum and urinary inorganic fluoride concentrations with renal and hepatic functions after repeated sevoflurane anesthesia. / Takenami, Tamie; Arai, Masayasu; Matsuzaki, Shigeyuki; Anzai, Ken; Ueno, Tetsuo; Hoka, Sumio.

In: Japanese Journal of Anesthesiology, Vol. 51, No. 10, 01.10.2002, p. 1086-1093.

Research output: Contribution to journalArticle

Takenami, T, Arai, M, Matsuzaki, S, Anzai, K, Ueno, T & Hoka, S 2002, 'Serum and urinary inorganic fluoride concentrations with renal and hepatic functions after repeated sevoflurane anesthesia', Japanese Journal of Anesthesiology, vol. 51, no. 10, pp. 1086-1093.
Takenami, Tamie ; Arai, Masayasu ; Matsuzaki, Shigeyuki ; Anzai, Ken ; Ueno, Tetsuo ; Hoka, Sumio. / Serum and urinary inorganic fluoride concentrations with renal and hepatic functions after repeated sevoflurane anesthesia. In: Japanese Journal of Anesthesiology. 2002 ; Vol. 51, No. 10. pp. 1086-1093.
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AU - Ueno, Tetsuo

AU - Hoka, Sumio

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