Serum antibody level against GroEL type heat-shock protein of Campylobacter jejuni in patients with Guillain-Barre syndrome

Shuji Fujimoto, Masaki Fujita

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recently there has been an increase in the number of cases reported of Guillain-Barre syndrome (GBS) developed after Campylobacter jejuni infection. To investigate the role of a C. jejuni GroEL-type heat-shock protein (CjHsp60) in the infection and induction of GBS, we examined the antibody level against CjHsp60 in 27 human sera, including GBS and non-GBS patients, by an enzyme-linked immunosorbent assay. Sera from patients with C. jejuni infection, despite the development of GBS, had a higher titer of anti- CjHsp60 antibody than those of patients without the infection and healthy control subjects. The patients with C. jejuni infection followed by GBS had slightly higher levels of this antibody than did the patients with infection who did not develop GBS, but there was no statistical significance. In conclusion, CjHsp60 is found to be one of the major immunogenic antigens in actual C. jejuni infection, but no evidence that supports the direct relationship between this protein and C. jejuni-associated GBS was found in this study.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume43
Issue number3
DOIs
Publication statusPublished - Jan 1 1999

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Campylobacter jejuni
Guillain-Barre Syndrome
Heat-Shock Proteins
Campylobacter Infections
Antibodies
Serum
Infection Control
Protein C
Infection
Anti-Idiotypic Antibodies
Healthy Volunteers
Enzyme-Linked Immunosorbent Assay
Antigens

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Virology

Cite this

Serum antibody level against GroEL type heat-shock protein of Campylobacter jejuni in patients with Guillain-Barre syndrome. / Fujimoto, Shuji; Fujita, Masaki.

In: MICROBIOLOGY and IMMUNOLOGY, Vol. 43, No. 3, 01.01.1999, p. 241-244.

Research output: Contribution to journalArticle

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