Serum antibody response to tuberculosis-associated glycolipid antigen after BCG vaccination in adults

Shigeki Nabeshima, Masayuki Murata, Kenichiro Kashiwagi, Masaki Fujita, Norihiro Furusyo, Jun Hayashi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Tuberculous glycolipid antigens (TBGLs) are derived from the cell walls of Mycobacterium tuberculosis. Detection of anti-TBGL antibody in serum has recently become possible for the serodiagnosis of active tuberculosis. TBGL is not indigenous to M. tuberculosis, but it is widely found in Mycobacterium species. To elucidate the influence of M. bovis bacille Calinette-Guérin (BCG) vaccination, we assayed serum anti-TBGL antibody after BCG vaccination in adults. BCG vaccination was done for 20 Japanese healthcare workers with a negative tuberculin skin test reaction, and serum was collected 0, 2, 4, and 8 weeks and 1 year after vaccination. The tuberculin skin test became positive in 85% of the subjects. The mean anti-TBGL antibody titer remained negative throughout the observation period, but was elevated significantly compared with the pre-vaccination level, peaking at week 4 and showing a reduced level 1 year post-vaccination. These results showed that serological diagnosis using anti-TBGL antibody was not influenced by prior BCG vaccination.

Original languageEnglish
Pages (from-to)256-258
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume11
Issue number5
DOIs
Publication statusPublished - Oct 2005

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Serum antibody response to tuberculosis-associated glycolipid antigen after BCG vaccination in adults'. Together they form a unique fingerprint.

Cite this