Serum antibody to Porphyromonas gingivalis and periodontitis progression: The Hisayama Study

Kenji Takeuchi, Michiko Furuta, Toru Takeshita, Yukie Shibata, Yoshihiro Shimazaki, Sumio Akifusa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshihisa Yamashita

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Abstract

Aim To assess the effectiveness of serum titres of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in a community-dwelling adult population. Materials and Methods This 4-year follow-up cohort study included 183 Japanese individuals (75 men and 108 women) aged 40-49 years. The clinical attachment level was measured at two sites on all teeth present at baseline and follow-up, and periodontitis progression was defined as progression in attachment loss of ≥3 mm at ≥2 measurement sites. Serum titres of antibody to Porphyromonas gingivalis were evaluated at baseline and served as the primary predictor variable for periodontitis progression. Results Periodontitis progression was found in 8.7% subjects. In a multivariate logistic regression model, higher titres of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titres of antibody to Porphyromonas gingivalis per 10 units: odds ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27). Conclusions Elevated serum titres of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

Original languageEnglish
Pages (from-to)719-725
Number of pages7
JournalJournal of Clinical Periodontology
Volume42
Issue number8
DOIs
Publication statusPublished - Jan 1 2015

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Porphyromonas gingivalis
Periodontitis
Antibodies
Serum
Logistic Models
Odds Ratio
Confidence Intervals
Independent Living
Confounding Factors (Epidemiology)
Tooth
Cohort Studies
Population

All Science Journal Classification (ASJC) codes

  • Periodontics

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Serum antibody to Porphyromonas gingivalis and periodontitis progression : The Hisayama Study. / Takeuchi, Kenji; Furuta, Michiko; Takeshita, Toru; Shibata, Yukie; Shimazaki, Yoshihiro; Akifusa, Sumio; Ninomiya, Toshiharu; Kiyohara, Yutaka; Yamashita, Yoshihisa.

In: Journal of Clinical Periodontology, Vol. 42, No. 8, 01.01.2015, p. 719-725.

Research output: Contribution to journalArticle

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abstract = "Aim To assess the effectiveness of serum titres of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in a community-dwelling adult population. Materials and Methods This 4-year follow-up cohort study included 183 Japanese individuals (75 men and 108 women) aged 40-49 years. The clinical attachment level was measured at two sites on all teeth present at baseline and follow-up, and periodontitis progression was defined as progression in attachment loss of ≥3 mm at ≥2 measurement sites. Serum titres of antibody to Porphyromonas gingivalis were evaluated at baseline and served as the primary predictor variable for periodontitis progression. Results Periodontitis progression was found in 8.7{\%} subjects. In a multivariate logistic regression model, higher titres of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titres of antibody to Porphyromonas gingivalis per 10 units: odds ratio, 1.66; 95{\%} confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95{\%} confidence interval, 1.20-14.27). Conclusions Elevated serum titres of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.",
author = "Kenji Takeuchi and Michiko Furuta and Toru Takeshita and Yukie Shibata and Yoshihiro Shimazaki and Sumio Akifusa and Toshiharu Ninomiya and Yutaka Kiyohara and Yoshihisa Yamashita",
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AU - Takeuchi, Kenji

AU - Furuta, Michiko

AU - Takeshita, Toru

AU - Shibata, Yukie

AU - Shimazaki, Yoshihiro

AU - Akifusa, Sumio

AU - Ninomiya, Toshiharu

AU - Kiyohara, Yutaka

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N2 - Aim To assess the effectiveness of serum titres of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in a community-dwelling adult population. Materials and Methods This 4-year follow-up cohort study included 183 Japanese individuals (75 men and 108 women) aged 40-49 years. The clinical attachment level was measured at two sites on all teeth present at baseline and follow-up, and periodontitis progression was defined as progression in attachment loss of ≥3 mm at ≥2 measurement sites. Serum titres of antibody to Porphyromonas gingivalis were evaluated at baseline and served as the primary predictor variable for periodontitis progression. Results Periodontitis progression was found in 8.7% subjects. In a multivariate logistic regression model, higher titres of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titres of antibody to Porphyromonas gingivalis per 10 units: odds ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27). Conclusions Elevated serum titres of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

AB - Aim To assess the effectiveness of serum titres of antibody to Porphyromonas gingivalis in the prediction of periodontitis progression in a community-dwelling adult population. Materials and Methods This 4-year follow-up cohort study included 183 Japanese individuals (75 men and 108 women) aged 40-49 years. The clinical attachment level was measured at two sites on all teeth present at baseline and follow-up, and periodontitis progression was defined as progression in attachment loss of ≥3 mm at ≥2 measurement sites. Serum titres of antibody to Porphyromonas gingivalis were evaluated at baseline and served as the primary predictor variable for periodontitis progression. Results Periodontitis progression was found in 8.7% subjects. In a multivariate logistic regression model, higher titres of antibody to Porphyromonas gingivalis and male gender were significantly associated with greater odds of periodontitis progression, even after adjustment for other confounding variables (titres of antibody to Porphyromonas gingivalis per 10 units: odds ratio, 1.66; 95% confidence interval, 1.16-2.36; male gender: odds ratio, 4.13; 95% confidence interval, 1.20-14.27). Conclusions Elevated serum titres of antibody to Porphyromonas gingivalis may be a risk factor for periodontitis progression.

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