Serum appearance of anti-p53 antibody in triple negative breast cancer

Tadahiro Nozoe, Emiko Mori, Mayuko Kono, Tomohiro Iguchi, Takashi Maeda, Akito Matsukuma, Takahiro Ezaki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Significance of serum appearance of anti-p53 antibody in breast cancer has not been discussed fully. Methods: The relationship between serum appearance of anti-p53 antibody and the clinicopathological features was investigated on the basis of the data of 42 women with breast cancer who had been treated with surgical resection. Results: The proportion of tumors with histological grade 3 was significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.020). The proportion of triple negative tumors was also significantly higher among tumors with serum appearance of anti-p53 antibody (P = 0.003). Conclusions: Preoperative appearance of anti-p53 antibody in sera can be correlated with the incidence of triple negative breast cancer and could therefore help identify tumors with aggressive potential.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBreast Cancer
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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    Nozoe, T., Mori, E., Kono, M., Iguchi, T., Maeda, T., Matsukuma, A., & Ezaki, T. (2012). Serum appearance of anti-p53 antibody in triple negative breast cancer. Breast Cancer, 19(1), 11-15. https://doi.org/10.1007/s12282-010-0244-3