Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus

Masataka Suwa, Hiro Kishimoto, Yu Nofuji, Hiroshi Nakano, Haruka Sasaki, Zsolt Radak, Shuzo Kumagai

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Abstract

Previous studies have demonstrated that brain-derived neurotrophic factor (BDNF) played a role in the eating behavior and glucose and lipid metabolism. In this study we measured the serum BDNF levels in newly diagnosed female patients with type 2 diabetes mellitus (n = 24, aged 34-59 years) and female subjects with normal glucose tolerance (n = 7, aged 34-56 years). The serum BDNF level was found to significantly increase in diabetic patients in comparison to that in healthy subjects (P < .05). In these patients, the serum BDNF level showed positive correlation with the body mass index (r = 0.535, P < .01), the percentage of body fat (r = 0.552, P < .01), the subcutaneous fat area based on computed tomography scan (r = 0.480, P < .05), the triglyceride level (r = 0.470, P < .05), the fasting blood glucose level (r = 0.437, P < .05), and the homeostasis model assessment of insulin resistance score (r = 0.506, P < .05), whereas it showed a negative correlation with age (r = -0.486, P < .05). The partial correlation coefficients adjusted by age showed significant differences regarding the body mass index (r = 0.423, P < .05), percentage of body fat (r = 0.504, P < .05), and triglyceride level (r = 0.426, P < .05). These results provide the first evidence that an increased BDNF is associated with a prevalence of type 2 diabetes mellitus. In addition, the BDNF is related to the total and abdominal subcutaneous fat mass and energy metabolism in the newly diagnosed female patients with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)852-857
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume55
Issue number7
DOIs
Publication statusPublished - Jul 1 2006

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Brain-Derived Neurotrophic Factor
Type 2 Diabetes Mellitus
Obesity
Serum
Adipose Tissue
Triglycerides
Body Mass Index
Abdominal Subcutaneous Fat
Glucose
Subcutaneous Fat
Feeding Behavior
Lipid Metabolism
Energy Metabolism
Insulin Resistance
Blood Glucose
Fasting
Healthy Volunteers
Homeostasis
Tomography

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. / Suwa, Masataka; Kishimoto, Hiro; Nofuji, Yu; Nakano, Hiroshi; Sasaki, Haruka; Radak, Zsolt; Kumagai, Shuzo.

In: Metabolism: Clinical and Experimental, Vol. 55, No. 7, 01.07.2006, p. 852-857.

Research output: Contribution to journalArticle

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