Serum Brain Natriuretic Peptide Concentration 60 Days after Surgery as a Predictor of Long-Term Prognosis in Patients Implanted with a Left Ventricular Assist Device

Takuma Sato, Osamu Seguchi, Yoshio Iwashima, Masanobu Yanase, Seiko Nakajima, Michinari Hieda, Takuya Watanabe, Haruki Sunami, Yoshihiro Murata, Hiroki Hata, Tomoyuki Fujita, Junjiro Kobayashi, Takeshi Nakatani

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9 Citations (Scopus)

Abstract

Mechanical circulatory support by a left ventricular assist device (LVAD) is used to bridge patients with advanced heart failure to transplant or as a definitive treatment. We retrospectively sought predictors of long-term outcome in a cohort of 83 patients who had undergone LVAD treatment. We subjected perioperative clinical data of patients to statistical analysis to establish parameters associated with all-cause mortality, and the cutoff values, sensitivity, and specificity of those that had a statistically significant relation with survival. Mean follow-up was 717 days (standard deviation, 334 days; range, 17-1,592 days). Fourteen patients (16.8%) died, but nine (10.8%) were weaned from support. Serum brain natriuretic peptide (BNP) concentration measured 60 days after implantation was significantly associated with all-cause mortality. The optimal BNP cutoff value to predict death during LVAD support was 322 pg/ml, with a sensitivity of 71.4% and specificity of 79.8%. Two-year survival was 92.0% in those with 60 days serum BNP concentration <322 pg/ml compared with 70.5% in those in whom it was ≥322 pg/ml (p = 0.003). The relation between BNP and survival likely reflects recovery of native myocardial function and improvements in global health and should assist clinicians in the on-going management of long-term LVAD therapy.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalASAIO Journal
Volume61
Issue number4
DOIs
Publication statusPublished - Jul 21 2015

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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    Sato, T., Seguchi, O., Iwashima, Y., Yanase, M., Nakajima, S., Hieda, M., Watanabe, T., Sunami, H., Murata, Y., Hata, H., Fujita, T., Kobayashi, J., & Nakatani, T. (2015). Serum Brain Natriuretic Peptide Concentration 60 Days after Surgery as a Predictor of Long-Term Prognosis in Patients Implanted with a Left Ventricular Assist Device. ASAIO Journal, 61(4), 373-378. https://doi.org/10.1097/MAT.0000000000000234