Serum elaidic acid concentration and risk of dementia: The Hisayama Study

Takanori Honda, Tomoyuki Ohara, Masakazu Shinohara, Jun Hata, Ryuji Toh, Daigo Yoshida, Mao Shibata, Tatsuro Ishida, Yoichiro Hirakawa, Yasuhiro Irino, Satoko Sakata, Kazuhiro Uchida, Takanari Kitazono, Shigenobu Kanba, Ken Ichi Hirata, Toshiharu Ninomiya

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

Original languageEnglish
Pages (from-to)e2053-e2064
JournalNeurology
Volume93
Issue number22
DOIs
Publication statusPublished - Nov 26 2019

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Dementia
Alzheimer Disease
Serum
Vascular Dementia
Trans Fatty Acids
elaidic acid
Primary Prevention
Public Policy
Health Policy
Energy Intake
Unsaturated Fatty Acids
Proportional Hazards Models
Gas Chromatography-Mass Spectrometry
Fatty Acids
Public Health
Biomarkers
Fats

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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Serum elaidic acid concentration and risk of dementia : The Hisayama Study. / Honda, Takanori; Ohara, Tomoyuki; Shinohara, Masakazu; Hata, Jun; Toh, Ryuji; Yoshida, Daigo; Shibata, Mao; Ishida, Tatsuro; Hirakawa, Yoichiro; Irino, Yasuhiro; Sakata, Satoko; Uchida, Kazuhiro; Kitazono, Takanari; Kanba, Shigenobu; Hirata, Ken Ichi; Ninomiya, Toshiharu.

In: Neurology, Vol. 93, No. 22, 26.11.2019, p. e2053-e2064.

Research output: Contribution to journalArticle

Honda, Takanori ; Ohara, Tomoyuki ; Shinohara, Masakazu ; Hata, Jun ; Toh, Ryuji ; Yoshida, Daigo ; Shibata, Mao ; Ishida, Tatsuro ; Hirakawa, Yoichiro ; Irino, Yasuhiro ; Sakata, Satoko ; Uchida, Kazuhiro ; Kitazono, Takanari ; Kanba, Shigenobu ; Hirata, Ken Ichi ; Ninomiya, Toshiharu. / Serum elaidic acid concentration and risk of dementia : The Hisayama Study. In: Neurology. 2019 ; Vol. 93, No. 22. pp. e2053-e2064.
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abstract = "OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.",
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T1 - Serum elaidic acid concentration and risk of dementia

T2 - The Hisayama Study

AU - Honda, Takanori

AU - Ohara, Tomoyuki

AU - Shinohara, Masakazu

AU - Hata, Jun

AU - Toh, Ryuji

AU - Yoshida, Daigo

AU - Shibata, Mao

AU - Ishida, Tatsuro

AU - Hirakawa, Yoichiro

AU - Irino, Yasuhiro

AU - Sakata, Satoko

AU - Uchida, Kazuhiro

AU - Kitazono, Takanari

AU - Kanba, Shigenobu

AU - Hirata, Ken Ichi

AU - Ninomiya, Toshiharu

PY - 2019/11/26

Y1 - 2019/11/26

N2 - OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

AB - OBJECTIVE: The associations between trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. METHODS: In total, 1,628 Japanese community residents aged 60 and older without dementia were followed prospectively from when they underwent a screening examination in 2002-2003 to November 2012 (median 10.3 years, interquartile range 7.2-10.4 years). Serum elaidic acid levels were measured using gas chromatography/mass spectrometry and divided into quartiles. The Cox proportional hazards model was used to estimate the hazard ratios for all-cause dementia, Alzheimer disease (AD), and vascular dementia by serum elaidic acid levels. RESULTS: During the follow-up, 377 participants developed some type of dementia (247 AD, 102 vascular dementia). Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for trend = 0.003) and AD (p for trend = 0.02) after adjustment for traditional risk factors. These associations remained significant after adjustment for dietary factors, including total energy intake and intakes of saturated and polyunsaturated fatty acids (both p for trend <0.05). No significant associations were found between serum elaidic acid levels and vascular dementia. CONCLUSIONS: The findings suggest that higher serum elaidic acid is a possible risk factor for the development of all-cause dementia and AD in later life. Public health policy to reduce industrially produced trans fatty acids may assist in the primary prevention of dementia.

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