TY - JOUR
T1 - Serum ferritin is associated with markers of insulin resistance in Japanese men but not in women
AU - Pham, Ngoc Minh
AU - Nanri, Akiko
AU - Yi, Siyan
AU - Kurotani, Kayo
AU - Akter, Shamima
AU - Foo, Leng Huat
AU - Nishi, Nobuo
AU - Sato, Masao
AU - Hayabuchi, Hitomi
AU - Mizoue, Tetsuya
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research (B) ( 21390213 ) from the Japan Society for the Promotion of Science (To Dr Mizoue), a Grant-in-Aid for Young Scientists (B) ( 21790598 ) from the Ministry of Education, Culture, Sports, Science and Technology and a Grant of National Center for Global Health and Medicine (To Dr Nanri).
PY - 2013/4
Y1 - 2013/4
N2 - Objective: Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR. Our aim was to examine the relationship between serum ferritin concentrations and IR markers in the Japanese population. Materials/Methods: We analyzed data (n = 493) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68 years. Fasting serum ferritin and insulin levels and fasting plasma glucose levels were determined, and the homeostatic model assessment of IR (HOMA-IR) was calculated. Multiple regression analysis was performed with adjustments for demographic and lifestyle factors, body mass index and serum C-reactive protein. Results: Fasting insulin and HOMA-IR significantly increased with increasing levels of serum ferritin after adjustment for covariates in men (P for trend =.005 and.001, respectively). Compared with men in the lowest tertile of serum ferritin, those in the highest tertile had a 24% higher HOMA-IR score. Additional data suggested a positive association between iron intake and HOMA-IR (P for trend =.07) in men. Neither serum ferritin nor iron intake was related to IR markers in women, even in postmenopausal women. Conclusions: Serum ferritin concentrations were positively associated with fasting insulin and HOMA-IR in men but not in women, suggesting an important role of iron storage in the pathogenesis of IR in Japanese men.
AB - Objective: Several epidemiological studies have reported that high concentrations of circulating ferritin, a marker of iron stores, are related to insulin resistance (IR); however, questions remain regarding inconsistent data between Asian men and women and the inadequate consideration of potential confounding effects on the relationship between ferritin and IR. Our aim was to examine the relationship between serum ferritin concentrations and IR markers in the Japanese population. Materials/Methods: We analyzed data (n = 493) from a cross-sectional survey conducted in 2009 among a Japanese working population aged 20-68 years. Fasting serum ferritin and insulin levels and fasting plasma glucose levels were determined, and the homeostatic model assessment of IR (HOMA-IR) was calculated. Multiple regression analysis was performed with adjustments for demographic and lifestyle factors, body mass index and serum C-reactive protein. Results: Fasting insulin and HOMA-IR significantly increased with increasing levels of serum ferritin after adjustment for covariates in men (P for trend =.005 and.001, respectively). Compared with men in the lowest tertile of serum ferritin, those in the highest tertile had a 24% higher HOMA-IR score. Additional data suggested a positive association between iron intake and HOMA-IR (P for trend =.07) in men. Neither serum ferritin nor iron intake was related to IR markers in women, even in postmenopausal women. Conclusions: Serum ferritin concentrations were positively associated with fasting insulin and HOMA-IR in men but not in women, suggesting an important role of iron storage in the pathogenesis of IR in Japanese men.
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U2 - 10.1016/j.metabol.2012.07.025
DO - 10.1016/j.metabol.2012.07.025
M3 - Article
C2 - 23107390
AN - SCOPUS:84884212181
VL - 62
SP - 561
EP - 567
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 4
ER -