Serum Folate and Depressive Symptoms Among Japanese Men and Women: A Cross-Sectional and Prospective Study

Akiko Nanri, Hitomi Hayabuchi, Masanori Ohta, Masao Sato, Norio Mishima, Tetsuya Mizoue

Research output: Contribution to journalArticle

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Abstract

Although several studies have reported an association between blood folate concentrations and depressive symptoms, few studies have prospectively examined the association. This study aimed to investigate the cross-sectional and prospective associations between serum folate concentrations and depressive symptoms among Japanese. We analysed data among 545 subjects who participated in a health survey at the time of periodic check-up in 2009 for a cross-sectional association and among 272 subjects without depressive symptoms at baseline (in 2006) who responded to both baseline (2006) and follow-up (2009) surveys for prospective association. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. In a cross-sectional analysis, serum folate concentrations were significantly associated with a decreased prevalence of depressive symptoms (CES-D scale of ≥16). Moreover, serum folate concentrations at baseline were significantly inversely associated with depressive symptoms after 3 years; the multivariate-adjusted odds ratios (95% confidence intervals) of depressive symptoms for the lowest through highest tertile categories of serum folate concentrations were 1.00 (reference), 0.66 (0.29-1.52) and 0.40 (0.16-0.99) (P for trend=0.047). Our findings suggest that a higher serum folate may be associated with decreased risk of depressive symptoms in Japanese.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalPsychiatry research
Volume200
Issue number2-3
DOIs
Publication statusPublished - Dec 30 2012

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Folic Acid
Cross-Sectional Studies
Prospective Studies
Depression
Serum
Epidemiologic Studies
Health Surveys
Odds Ratio
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Serum Folate and Depressive Symptoms Among Japanese Men and Women : A Cross-Sectional and Prospective Study. / Nanri, Akiko; Hayabuchi, Hitomi; Ohta, Masanori; Sato, Masao; Mishima, Norio; Mizoue, Tetsuya.

In: Psychiatry research, Vol. 200, No. 2-3, 30.12.2012, p. 349-353.

Research output: Contribution to journalArticle

Nanri, Akiko ; Hayabuchi, Hitomi ; Ohta, Masanori ; Sato, Masao ; Mishima, Norio ; Mizoue, Tetsuya. / Serum Folate and Depressive Symptoms Among Japanese Men and Women : A Cross-Sectional and Prospective Study. In: Psychiatry research. 2012 ; Vol. 200, No. 2-3. pp. 349-353.
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